347-12-6

Basic information

• Product Name: 2-(4-FLUORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE
• Synonyms: 2-(4-FLUORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE;BUTTPARK 7\05-95
• CAS NO: 347-12-6
• Molecular Formula: C₁₃H₉FN₂
• Molecular Weight: 212.22
• Mol File: 347-12-6.mol
• Article Data: 72

Chemical Properties

• Melting Point: 165-166 °C
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 6.54±0.50(Predicted)
• CAS DataBase Reference: 2-(4-FLUORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(347-12-6)
• EPA Substance Registry System: 2-(4-FLUORO-PHENYL)-IMIDAZO[1,2-A]PYRIDINE(347-12-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26
• Hazardous Substances Data: 347-12-6(Hazardous Substances Data)

Usage

Uses

2-(4-Fluorophenyl)imidazo[1,2-a]pyridine

Upstream product

• 504-29-0 2-aminopyridine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 158958-70-4 2-(4-fluorophenyl)-3-chloroimidazo<1,2-a>pyridine 
• 357952-79-5 1-(4-fluorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 591-50-4 iodobenzene 
• 426825-66-3 6-bromo-2-(4-fluoropjhenyl)imidazo[1,2-a]pyridine 
• 960-16-7 tributylphenylstannane 
• 478040-44-7 6-iodo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 208934-35-4 4-(tributylstannyl)-1-triphenylmethyl-1H-imidazole 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 3488-44-6 1-(4-fluorophenyl)-2-diazoethan-1-one 
• 26031-63-0 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide 
• 1021019-74-8 imidazo[1,2-a]pyridin-2-yl trifluoromethanesulfonate 
• 1765-93-1 4-fluoroboronic acid 

Downstream Products

• 158958-70-4 2-(4-fluorophenyl)-3-chloroimidazo<1,2-a>pyridine 
• 307503-17-9 3-iodo-2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 1115604-53-9 2-(4'-fluorophenyl)-3-nitrosoimidazo[1,2-a]pyridine 
• 158958-74-8 3-bromo-2-(4'-fluorophenyl)imidazo[1,2-a]pyridine 
• 1345965-03-8 3-(diphenylphosphorothioyl)-2-(4-fluorophenyl)imidazo[1,2-a]pyridine 
• 1353511-78-0 C₁₈H₁₂FN₃ 
• 1353511-80-4 C₁₉H₁₂FN₃O₂ 
• 1463476-25-6 1-ethyl-2-(4-fluorophenyl)imidazo[1,2-a]pyridinium iodide 
• 425658-37-3 2-(4-fluorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde 

Relevant articles and documents

A multi pathway coupled domino strategy: I2/ TBHP-promoted synthesis of imidazopyridines and thiazoles via sp3, sp2 and sp C-H functionalization

I2/TBHP-promoted, one-pot, multi pathway synthesis of imidazopyridines and thiazoles has been achieved through readily available ethylarenes, ethylenearenes and ethynearenes. I2/TBHP as an initiator and oxidant is used to realize the C-H functionalization of this domino reaction. Simple and available starting materials, wide range of functional group tolerance, high potential for drug activity of the products and application in production are the advantageous features of this method.

Electrochemical Oxidative C3 Acyloxylation of Imidazo[1,2- a]pyridines with Hydrogen Evolution

The C3-functionalized imidazo[1,2-a]pyridines are versatile nitrogen-fused heterocycles; however, the methods for the C3 acyloxylation of imidazo[1,2-a]pyridines have never been reported. Herein we demonstrate the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines for the first time. Notably, by using electricity, the electrochemical oxidative C3 acyloxylation of imidazo[1,2-a]pyridines was carried out under mild conditions. Moreover, in addition to aromatic carboxylic acids, alkyl carboxylic acids were also competent substrates.

Oxidation Potential-Guided Electrochemical Radical-Radical Cross-Coupling Approaches to 3-Sulfonylated Imidazopyridines and Indolizines

Oxidation potential-guided electrochemical radical-radical cross-coupling reactions between N-heteroarenes and sodium sulfinates have been established. Thus, simple cyclic voltammetry measurement of substrates predicts the likelihood of successful radical-radical coupling reactions, allowing the simple and direct synthetic access to 3-sulfonylated imidazopyridines and indolizines. The developed electrochemical radical-radical cross-coupling reactions to sulfonylated N-heteroarenes boast the green synthetic nature of the reactions that are oxidant- and metal-free.