347-40-0

Basic information

• Product Name: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE
• Synonyms: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE;6-Trifluoromethyl-3,4-dihydro-2H-benzo[1,4]oxazine;3,4-Dihydro-6-(trifluoromethyl)-2H-1,4-benzoxazine 97%;3,4-Dihydro-6-(trifluoromethyl)-2H-benzo[b][1,4]oxazine;3,4-Dihydro-6-(trifluoromethyl)-2H-1,4-benzoxazine97%;6-(trifluoromethyl)-3,4-dihydro-2H-1,4-benzoxazine
• CAS NO: 347-40-0
• Molecular Formula: C9H9ClF3NO
• Molecular Weight: 239.6220696
• Mol File: 347-40-0.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE(347-40-0)
• EPA Substance Registry System: 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE(347-40-0)

Safety Data

• Hazardous Substances Data: 347-40-0(Hazardous Substances Data)

Usage

General Description

6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE is a chemical compound with the molecular formula C8H8F3NO·HCl. It is a white to off-white solid that is soluble in water. 6-TRIFLUOROMETHYL-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE is of interest in pharmaceutical research as it exhibits potential biological activity. It is a heterocyclic compound with a tricyclic structure, making it a versatile molecule for medicinal chemistry applications. The hydrochloride salt form of this compound enhances its solubility and stability, making it easier to handle and administer in research and development. Its unique chemical structure and potential biological activity make it a valuable target for further study and potential drug development.

Upstream product

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Relevant articles and documents

COMPOUND HAVING 11 ?-HSD1 INHIBITORY ACTIVITY

The present invention provides compounds having excellent 11β-HSD1 inhibitory activity. A compound represented by the following formula (I): [wherein X1 represents an oxygen atom, or the formula -(CR11R12)p-, etc., Y1 represents a hydrogen atom, a hydroxyl group, etc., Z1 represents an oxygen atom or the formula -(NR14)-, R1 represents a hydrogen atom, a halogen atom, a cyano group, a C1-4 alkyl group, a C1-4 alkyl group substituted with 1 to 3 halogen atoms, a C1-4 alkoxy group, a C1-4 alkoxycarbonyl group, a carboxyl group, a carbamoyl group, or an amino group, and m represents an integer of 1 or 2, and R2 represents a hydrogen atom or a C1-4 alkyl group, and n represents an integer of 1 or 2].

Production Method of Nitrogen-Containing Fused Ring Compounds

[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like. [Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained. wherein each symbol is as defined in the description.

Synthesis of substituted 4-(3-alkyl-1,2,4-oxadiazol-5-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines and 4-(1H-benzimidazol-2-ylmethyl)-3,4-dihydro-2H-1,4-benzoxazines

Substituted 2H-1,4-benzoxazines were synthesized from substituted 2-amino phenols and 1,2-dibromoethane using K2CO3 in good to excellent yields. The cyclized products were further reacted with alkyl bromides to obtain the desired N-substituted 3,4-dihydro-2H-1,4-benzoxazines.