3471-05-4 Usage
Description
Anabaseine is a naturally occurring neurotoxin derived from hoplonemertine sea worms. It is known for its ability to compete with the natural neurotransmitter acetylcholine when binding to nicotinic receptor sites.
Uses
Used in Pharmaceutical Industry:
Anabaseine is used as a therapeutic agent for the treatment of nicotine addiction and smoking cessation. Its ability to compete with acetylcholine at nicotinic receptor sites helps to reduce cravings and withdrawal symptoms associated with nicotine dependence.
Used in Neurological Research:
Anabaseine is used as a research tool in the study of nicotinic acetylcholine receptors and their role in various neurological disorders. Its interaction with these receptors provides valuable insights into the development of potential treatments for conditions such as Alzheimer's disease, Parkinson's disease, and schizophrenia.
Used in Toxicological Studies:
Anabaseine is used in toxicological research to understand the mechanisms of action and potential risks associated with neurotoxins. This knowledge can contribute to the development of antidotes and preventive measures against the harmful effects of similar toxins.
Check Digit Verification of cas no
The CAS Registry Mumber 3471-05-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 3,4,7 and 1 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 3471-05:
(6*3)+(5*4)+(4*7)+(3*1)+(2*0)+(1*5)=74
74 % 10 = 4
So 3471-05-4 is a valid CAS Registry Number.
3471-05-4Relevant articles and documents
Synthesis of cyclic imines via ethylenetetramethyldisilyl-protected ω-aminoimines. Application to the synthesis of alkaloids
De Kimpe, Norbert G.,Kepppens, Marian A.,Stevens, Christian V.
, p. 4693 - 4696 (1993)
Cyclic imines, including several alkaloids such as myosmine, anabaseine and apoferrorosamine, were synthesized by α-alkylation of imines with ethylenetetramethyldisilyl-protected ω-bromoamines, followed by ring closure.
The reaction of cyclic imines with the Ruppert-Prakash reagent. Facile approach to α-trifluoromethylated nornicotine, anabazine, and homoanabazine
Shevchenko, Nikolay E.,Vlasov, Katja,Nenajdenko, Valentine G.,R?schenthaler, Gerd-Volker
scheme or table, p. 69 - 74 (2011/02/27)
We have demonstrated that the Ruppert-Prakash reagent is able to react with a number of cyclic imines under acidic condition to afford the corresponding α-trifluoromethyl derivatives of nitrogen heterocycles. 5-7-Membered cyclic imines bearing various alkyl, aryl or heterocyclic group were successfully involved in this transformation. Novel trifluoromethylated analogues of nicotine, anabasine, and homoanabasine alkaloids were synthesized.
SYNTHESIS OF TOBACCO ALKALOIDS VIA TERTIARY AZIDES
Alberici, Gilles F.,Andrieux, Jean,Adam, Gerard,Plat, Michel M.
, p. 1937 - 1940 (2007/10/02)
A convenient new synthesis of different tobacco alkaloids, such as nicotine and anabasine is described, using as key step the SCHMIDT reaction applied to tertiary alcohols.
