34713-98-9

Basic information

• Product Name: (R)-(-)-α-methoxyphenylacetyl chloride
• Synonyms: (R)-(-)-α-methoxyphenylacetyl chloride
• CAS NO: 34713-98-9
• Molecular Weight: 184.622
• Mol File: 34713-98-9.mol
• Article Data: 77

Chemical Properties

• Boiling Point: 246.2±28.0 °C(Predicted)
• Density: 1.195±0.06 g/cm3(Predicted)
• CAS DataBase Reference: (R)-(-)-α-methoxyphenylacetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-α-methoxyphenylacetyl chloride(34713-98-9)
• EPA Substance Registry System: (R)-(-)-α-methoxyphenylacetyl chloride(34713-98-9)

Safety Data

• Hazardous Substances Data: 34713-98-9(Hazardous Substances Data)

Usage

Description

(R)-(-)-α-methoxyphenylacetyl chloride, with the molecular formula C9H9ClO2, is an acetyl chloride derivative that serves as an intermediate in the synthesis of various pharmaceuticals and organic compounds. This chiral molecule, characterized by a specific optical rotation, is widely used as a reagent in organic chemical reactions.

Uses

Used in Pharmaceutical Industry:
(R)-(-)-α-methoxyphenylacetyl chloride is used as an intermediate for the synthesis of chiral compounds, which are essential in the development of pharmaceutical drugs. Its role in creating these compounds is crucial for the production of various medications.
Used in Agricultural Products:
(R)-(-)-α-methoxyphenylacetyl chloride is also utilized in the preparation of chiral compounds for agricultural products, contributing to the development of more effective and targeted agrochemicals.
Used in Fragrance and Flavoring Industry:
(R)-(-)-α-methoxyphenylacetyl chloride is used as a building block in the creation of fragrances and flavoring agents, adding to the diversity and complexity of scents and tastes in various consumer products.
Used in Organic Synthesis:
As a versatile building block, (R)-(-)-α-methoxyphenylacetyl chloride is employed in organic synthesis, particularly in the pharmaceutical industry, where it plays a significant role in various chemical processes and the development of new compounds.

Upstream product

• 166180-82-1 (R S)-2-amino-3-[3-ethoxy-5-(2-thienyl)isoxazol-4-yl]propionic acid 
• 26164-26-1 (S)-2-methoxy-2-phenylacetic acid 
• 3966-32-3 (R)-methoxyphenylacetic acid 
• 79-37-8 oxalyl dichloride 
• 7021-09-2 rac-methoxyphenylacetic acid 
• 4755-72-0 Chloro-phenyl-acetic acid 

Downstream Products

• 67177-15-5 (S)-Methoxy-phenyl-acetic acid (1E,3E)-hexa-1,3-dienyl ester 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (S)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 65617-09-6 (S)-Methoxy-phenyl-acetic acid (R)-2-morpholin-4-yl-1-phenyl-ethyl ester 
• 121888-10-6 (S)-Methoxy-phenyl-acetic acid (R)-6-methyl-5-oxo-4,5,6,7-tetrahydro-cyclopenta[1,3]dioxin-6-yl ester 
• 121888-11-7 (S)-Methoxy-phenyl-acetic acid (S)-6-methyl-5-oxo-4,5,6,7-tetrahydro-cyclopenta[1,3]dioxin-6-yl ester 
• 7476-63-3 (+/-)-2-methoxy-2-phenylacetamide 
• 100-52-7 benzaldehyde 
• 74-87-3 methylene chloride 
• 864358-46-3 (R,R)-1,6-bis(α-methoxyphenylacetamido)phenazine 
• 95514-01-5 2-{6-[1-Benzyloxy-2-((R)-2-methoxy-2-phenyl-acetoxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propionic acid methyl ester 
• 3962-43-4 1,2-diphenyl-1,2-dimethoxy ethane, meso 
• 119702-44-2 1-(Methoxy-phenyl-methyl)-cyclohexanol 

Relevant articles and documents

Tandem Inter [4 + 2]/Intra [3 + 2] Cycloadditions. 17. The Spiro Mode. Efficient and Highly Selective Synthesis of Azapropellanes

A new variant of the tandem inter [4 + 2]/intra [3 + 2] nitroalkene cycloaddition has been developed. Intermolecular [4 + 2] cycloaddition of a 2-nitroalkene (bearing an unsaturated ester moiety, the dipolarophile) with a vinyl ether produces a cyclic nit

Forazoline A: Marine-Derived Polyketide with Antifungal in Vivo Efficacy

Forazoline A, a novel antifungal polyketide with in vivo efficacy against Candida albicans, was discovered using LCMS-based metabolomics to investigate marine-invertebrate-associated bacteria. Forazoline A had a highly unusual and unprecedented skeleton.

Mutual kinetic resolution of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines and 2-alkoxyacyl chlorides

[Figure not available: see fulltext.] Stereoselective acylation of racemic 3-methyl-3,4-dihydro-2Н-1,4-benzoxazine and its 7,8-difluoro-substituted analog with racemic 2-alkoxyacyl chlorides was stidied. The reactions of 3-methyl-3,4-dihydro-2H-1,4-benzoxazines with 2-methoxyisopentanoyl chloride were found to be more selective (selectivity factor s 31–32) compared to the acylation with other studied propanoyl chlorides (s 18–21). This fact was probably caused by the significant steric hindrance due to the isopropyl substituent in acyl chloride compared to the methyl group in reagents derived from propanoic acid.

An efficient method for the preparation of enantiomerically pure N- acylarylsulfonamides having an asymmetric center at the α-position: Condensation of acid chlorides and arylsulfonamides under solid-liquid two- phase conditions

A convenient synthetic method for the preparation of enantiomerically pure N-acylarylsulfonamides having an asymmetric center at the α-position of the carbonyl group is described. Chiral phenylacetic acids are first converted to the corresponding acid chl

C3-Symmetric Tricyclo[2.2.1.02,6]heptane-3,5,7-triol

A straightforward access to a hitherto unknown C3-symmetric tricyclic triol both in racemic and enantiopure forms has been developed. Treatment of 7-tert-butoxynorbornadiene with peroxycarboxylic acids provided mixtures of C1- and C3-symmetric 3,5,7-triacyloxynortricyclenes via transannular π-cyclization and replacement of the tert-butoxy group. By refluxing in formic acid, the C1-symmetric esters were converted to the C3-symmetric formate. Hydrolysis gave diastereoisomeric triols, which were separated by recrystallization. Enantiomer resolution via diastereoisomeric tri(O-methylmandelates) delivered the target triols on a gram scale. The pure enantiomers are useful as core units of dopants for liquid crystals.

The determination of the absolute configuration of a chiral 2,3′-diindolylarylmethane by NMR spectroscopy

The University of Chinese Academy of Sciences, Beijing 100864, China We present the determination of the absolute configuration of a chiral 2,3′-diindolylarylmethane 1 by using the combination of NMR spectroscopic and circular dichroism techniques. The re

Novel chiral biphenyl quaternary ammonium salt phase transfer catalyst and preparation method and application thereof

The invention discloses a novel chiral biphenyl quaternary ammonium salt phase transfer catalyst and a preparation method and application thereof. The catalyst comprises a compound A and a compound B.The molecular structure of the compound A is shown as a