34717-03-8

Basic information

• Product Name: MAGNESIUM OROTATE
• Synonyms: beta-4)-;bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylato-n3,o4)-magnesiu(;MAGNESIUM OROTATE;bis(1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylato-N3,O4)magnesium;magnesium oratate;Magnesium Orotate Dihydrate;Magnesium bis(2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate);MagnesiuM,bis(1,2,3,6-tetrahydro-2,6-dioxo-4-pyriMidinecarboxylato-kN3,kO4)-, (T-4)-
• CAS NO: 34717-03-8
• Molecular Formula: C10H6MgN4O8
• Molecular Weight: 334.48
• EINECS: 252-167-6
• Product Categories: Fine Chemical
• Mol File: 34717-03-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C
• CAS DataBase Reference: MAGNESIUM OROTATE(CAS DataBase Reference)
• NIST Chemistry Reference: MAGNESIUM OROTATE(34717-03-8)
• EPA Substance Registry System: MAGNESIUM OROTATE(34717-03-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34717-03-8(Hazardous Substances Data)

Usage

Description

Magnesium orotate is a magnesium salt of orotic acid, which is poorly soluble in water. It serves as a source of magnesium and is utilized as a mineral supplement to address magnesium deficiency. The orotic acid component functions as a transporter, facilitating the entry of magnesium into cells. Additionally, magnesium orotate possesses antioxidant properties, as orotic acid is a crucial intermediate in the biosynthetic pathway of pyrimidines, promoting the synthesis of enzymes that act as free radical scavengers. Ongoing experiments are exploring the potential cardioprotective effects of orotic acid in pathological heart conditions.

Uses

Used in Pharmaceutical Industry:
Magnesium orotate is used as an adjuvant treatment for various conditions, including congestive heart failure, hypertension, post-operative cardiac status, and type 2 diabetes. The combination of magnesium and orotic acid in magnesium orotate optimizes the magnesium effect by reducing cellular magnesium loss, providing cardioprotective properties.
Used in Cardiovascular Health:
Magnesium orotate is used to promote cardiovascular health by combining the cardioprotective properties of both magnesium and orotic acid. This leads to an optimization of the magnesium effect, which is crucial for maintaining heart health.
Used in Atherosclerosis Research:
Animal studies have indicated a protective effect of magnesium orotate with respect to atherosclerotic vascular changes. The efficacy of the combination of magnesium and orotic acid has been found to be superior to the individual effects of these components, making magnesium orotate a promising candidate for further research and potential applications in atherosclerosis treatment and prevention.

Preparation

For the synthesis of magnesium orotate and due to the low solubility of both magnesium hydroxide and orotic acid, 50 mL H2O were heated up to 70 °C. Half of the magnesium hydroxide (total: 0.125 g, 2.16 mmol, 1 eq.) was added to the warm solution. Subsequently, small amounts of both orotic acid (total: 0.75 g, 4.31 mmol, 2 eq.) and the remaining magnesium hydroxide were added alternatingly. After heating the solution to 90 °C and stirring it for 30 min, it was stored in the fridge for crystallization. After one weekend, 0.70 g (1.46 mmol, 68 %) of a white microcrystalline material could be obtained after filtration and drying.IR, NMR and PXRD analysis (presented in sections S2 and S4) confirmed the product to be magnesium orotate octahydrate.

InChI:InChI=1/2C5H4N2O4.Mg/c2*8-3-1-2(4(9)10)6-5(11)7-3;/h2*1H,(H,9,10)(H2,6,7,8,11);/q;;+2/p-2