348-35-6Relevant articles and documents
Highly chemoselective synthesis of benzimidazoles in Sc(OTf)3-catalyzed system
Fan, Liyan,Kong, Lulu,Chen, Wen
, p. 2306 - 2314 (2016/03/01)
The present researches elicit a simple, green and efficient method for the synthesis of substituted benzimidazoles through the coupling of o-phenylenediames with aldehydes catalyzed by Sc(OTf)3 in ethanol, which obtains high chemoselectivity and excellent yield of many biologically active 1,2-disubstitued and 2-substituted benzimidazoles respectively and are also environment friendly.
Discovery of benzimidazole derivatives as novel multi-target EGFR, VEGFR-2 and PDGFR kinase inhibitors
Li, Yunqi,Tan, Chunyan,Gao, Chunmei,Zhang, Cunlong,Luan, Xudong,Chen, Xiaowu,Liu, Hongxia,Chen, Yuzong,Jiang, Yuyang
supporting information; experimental part, p. 4529 - 4535 (2011/09/19)
Multi-target EGFR, VEGFR-2 and PDGFR inhibitors are highly useful anticancer agents with improved therapeutic efficacies. In this work, we used two virtual screening methods, support vector machines (SVM) and molecular docking, to identify a novel series
H2O2/Fe(NO3)3-promoted synthesis of 2-arylbenzimidazoles and 2-arylbenzothiazoles
Bahrami, Kiumars,Khodaei, Mohammad Mehdi,Naali, Fardin
experimental part, p. 569 - 572 (2009/06/25)
A new, convenient synthesis of 2-substituted benzimidazoles and benzothiazoles is described. Short reaction time, easy and quick isolation of the products, environmentally friendly procedure, excellent chemoselectivity and excellent yields are main advantages of this procedure. Georg Thieme Verlag Stuttgart.