34885-02-4

Basic information

• Product Name: 1-(3-AMINOPROPYL)PIPERAZINE
• Synonyms: RARECHEM AL BW 2024;N-AMINOPROPYL PIPERAZINE;1-(3-AMINOPROPYL)PIPERAZINE;3-PIPERAZIN-1-YL-PROPYLAMINE;piperazine-1-propylamine;3-(1-Piperazinyl)-1-propanamine;1-Piperazinepropanamine;1-Piperazinepropylamine
• CAS NO: 34885-02-4
• Molecular Formula: C₇H₁₇N₃
• Molecular Weight: 143.23
• EINECS: 252-270-6
• Product Categories: pharmacetical
• Mol File: 34885-02-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 240.0±8.0℃ (760 Torr)
• Flash Point: 98.9±18.4℃
• Appearance: /
• Density: 0.946±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.039mmHg at 25°C
• Refractive Index: 1.4974 (589.3 nm 25℃)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.39±0.10(Predicted)
• CAS DataBase Reference: 1-(3-AMINOPROPYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-AMINOPROPYL)PIPERAZINE(34885-02-4)
• EPA Substance Registry System: 1-(3-AMINOPROPYL)PIPERAZINE(34885-02-4)

Safety Data

• Hazardous Substances Data: 34885-02-4(Hazardous Substances Data)

Usage

General Description

1-(3-aminopropyl)piperazine is a chemical compound with the molecular formula C7H18N2. It is a member of the piperazine class of organic compounds and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs and other biologically active molecules. It is also known to possess anti-inflammatory and neuroprotective properties and has been studied for its potential therapeutic applications in the treatment of various neurological and psychiatric disorders. The compound can be synthesized through the reaction of piperazine with 3-chloropropylamine and is typically handled and stored as a colorless liquid with a characteristic amine odor. Its chemical structure and properties make it a valuable tool for drug development and research in the field of medicinal chemistry.

InChI:InChI=1/C7H17N3/c8-2-1-5-10-6-3-9-4-7-10/h9H,1-8H2

Upstream product

• 110-85-0 piperazine 
• 107-13-1 acrylonitrile 
• 503-29-7 azetidine 
• 910127-07-0 4-(3-benzyloxycarbonylamino-propyl)-piperazine-1-carboxylic acid benzyl ester 
• 156-87-6 propan-1-ol-3-amine 

Downstream Products

• 1285533-39-2 C₃₄H₃₉ClN₈O₂ 
• 1620172-27-1 C₈₈H₁₅₄N₁₆O₁₆ 

Relevant articles and documents

PROCESS TO PREPARE PROPYLENE AMINES AND PROPYLENE AMINE DERIVATIVES

The present invention relates to a process to prepare propylene amines of the formula NH2-(A-NH-)pR, wherein R is a hydrogen atom or an alkyl group, p is at least 1 when R is an alkyl group, and at least 2 when R is a hydrogen atom, or derivatives or precursors thereof wherein one or more units -NH-A-NH-may be present as a cyclic urea unit. (I) or a cyclic unit (ll) or between two units –NH-A-NH-a carbonyl bond is present, each unit –A-can be independently an alkylene unit and at least one unit –A-is a -C3H6- unit, wherein each -C3H6- unit can be linear or branched, by reacting (i) at least one of a hydroxy-functional compound chosen from the alkanolamine-functional compounds, and dihydroxyalkylene compounds, with (ii) an amine-functional compound,in the presence of (iii) a carbon oxide delivering agent, wherein at least one of the alkanolamine-functional compound, the amine-functional compound and/or the carbon oxide delivering agent contains at least one alkylene unit (A) that is a propylene unit

Synthesis and structure-activity relationships of truncated bisubstrate inhibitors of aminoglycoside 6′-N-acetyltransferases

Truncated aminoglycoside-coenzyme A bisubstrate analogues were efficiently prepared using a convergent approach where the amine and the thiol are coupled in one pot with the addition of a linker, without the need for protecting groups. These derivatives were tested for their effect on the activity of the resistance-causing enzyme aminoglycoside 6′-N-acetyltransferase Ii, and key structure-activity relationships are reported. Moreover, one of the inhibitors is able to block aminoglycoside resistance in cells expressing this enzyme.

Novel methods of preparation of 3-aminopropan-1-ol derivatives. II. Synthesis of 3-N-piperazinyl)-propan-1-ol and its derivatives.

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