349087-34-9

Basic information

• Product Name: JX401
• Synonyms: JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401
• CAS NO: 349087-34-9
• Molecular Formula: C21H25NO2S
• Molecular Weight: 355.49
• Product Categories: Intracellular Signaling
• Mol File: 349087-34-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.8 °C
• Appearance: /
• Density: 1.17 g/cm³
• Vapor Pressure: 1.28E-11mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Store at RT
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
• Stability: Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: JX401(CAS DataBase Reference)
• NIST Chemistry Reference: JX401(349087-34-9)
• EPA Substance Registry System: JX401(349087-34-9)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9/PG 3
• Hazardous Substances Data: 349087-34-9(Hazardous Substances Data)

Usage

Description

JX401, also known as a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM), is a compound that selectively targets the p38α isoform of MAP kinase without inhibiting the p38γ isoform. It plays a crucial role in various cellular processes, including cell differentiation and signal transduction.

Uses

Used in Pharmaceutical Industry:
JX401 is used as a potent, reversible inhibitor of the p38α isoform of MAP kinase for its effectiveness in mammalian cells. It is particularly useful in blocking the differentiation of myoblasts into myotubes, which can have significant implications in the study and treatment of various diseases and conditions related to cell differentiation and growth.
Used in Research Applications:
In the field of research, JX401 is used as a specific inhibitor of the p38α isoform MAP kinase to study its role in cellular processes and signal transduction pathways. This selective inhibition allows researchers to better understand the functions and interactions of the p38α isoform in various biological systems.
Used in Drug Development:
JX401 can be utilized in the development of new drugs targeting the p38α isoform of MAP kinase, which may have potential therapeutic applications in treating diseases and conditions related to the dysregulation of this specific protein. Its selective inhibition of p38α makes it a valuable tool in the development of targeted therapies with minimal off-target effects.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

InChI:InChI=1/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3