34966-48-8

Basic information

• Product Name: ETHYL 4-CHLOROBENZOYLFORMATE
• Synonyms: (4-CHLOROPHENYL)GLYOXYLIC ACID ETHYL ESTER;ETHYL 4-CHLOROBENZOYLFORMATE;ETHYL 2-(2,4-DICHLOROPHENYL)-2-OXOACETATE;ETHYL 2-(4-CHLOROPHENYL)-2-OXOACETATE;Ethyl (4-chlorophenyl)(oxo)acetate;Ethyl 4-chlorobenzoylformate Ethyl 2-(2,4-dichlorophenyl)-2-oxoacetate (4-Chlorophenyl)glyoxylic acid ethyl ester;Ethyl 4-chlorobenzoylformate, Ethyl 4-chlorophenylglyoxylate;Ethyl 4-chlorophenylglyoxylate
• CAS NO: 34966-48-8
• Molecular Formula: C₁₀H₉ClO₃
• Molecular Weight: 212.63
• Product Categories: Aromatic Esters
• Mol File: 34966-48-8.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 85°C/0.1mm
• Flash Point: 129 °C
• Appearance: /
• Density: 1.255 g/cm³
• Vapor Pressure: 0.000837mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: ETHYL 4-CHLOROBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-CHLOROBENZOYLFORMATE(34966-48-8)
• EPA Substance Registry System: ETHYL 4-CHLOROBENZOYLFORMATE(34966-48-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 34966-48-8(Hazardous Substances Data)

Usage

General Description

Ethyl 4-chlorobenzoylformate is a chemical compound with the molecular formula C10H9ClO3. It is a colorless to yellow liquid with a fruity odor, and is primarily used in the production of pharmaceuticals and agrochemicals. ETHYL 4-CHLOROBENZOYLFORMATE is an acylating agent, meaning it is used to transfer an acyl group from one molecule to another, and is commonly employed in the synthesis of various organic compounds. Ethyl 4-chlorobenzoylformate is considered to be a hazardous substance and should be handled with caution, as it can cause irritation to the skin, eyes, and respiratory system upon exposure.

InChI:InChI=1/C10H9ClO3/c1-2-14-10(13)9(12)7-3-5-8(11)6-4-7/h3-6H,2H2,1H3

Upstream product

• 13014-48-7 4-chlorobenzoyl cyanide 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 64-17-5 ethanol 
• 106-39-8 bromochlorobenzene 
• 75716-82-4 imidazol-1-yl-oxo-acetic acid ethyl ester 
• 4755-77-5 Ethyl oxalyl chloride 
• 108-90-7 chlorobenzene 
• 4383-55-5 3-hydroxy-2-(4-chlorophenyl)acrylic acid ethyl ester 
• 95-92-1 oxalic acid diethyl ester 
• 637-87-6 1-Chloro-4-iodobenzene 
• 122-01-0 4-chloro-benzoyl chloride 
• 1147869-47-3 ethyl (2Z)-3-(acetylamino)-2-(4-chlorophenyl)-3-phenylacrylate 
• 1147869-46-2 ethyl (2E)-3-(acetylamino)-2-(4-chlorophenyl)-3-phenylacrylate 
• 622-98-0 4-chloro(ethylbenzene) 

Downstream Products

• 99184-38-0 dichloro-(4-chloro-phenyl)-acetic acid ethyl ester 
• 33131-18-9 ethyl 2-(4-chlorophenyl)-3-methylbut-2-enoate 
• 93089-21-5 Cyclohexyl-<4-chlor-phenyl>-glykolsaeure-aethylester 
• 78587-62-9 [3-(4-Chloro-phenyl)-2-oxo-2H-benzo[1,4]oxazin-6-yl]-acetic acid methyl ester 
• 78587-67-4 2-[3-(4-Chloro-phenyl)-2-oxo-2H-benzo[1,4]oxazin-6-yl]-propionic acid methyl ester 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 443793-46-2 (R)-(-)-2-(4-chloro-phenyl)-2-hydroxy-3-nitro-propionic acid ethyl ester 
• 510-15-6 chlorobenzilate 
• 916058-72-5 ethyl (p-chlorophenyl)-[N-(p-methoxyphenyl)imino]acetate 
• 7477-64-7 (S)-1-(4-chlorophenyl)-1,2-ethanediol 

Relevant articles and documents

Diastereoselective Synthesis of α-Quaternary Aziridine-2-carboxylates via Aza-Corey-Chaykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters

A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant α-quaternary amino esters and derivatives starting from readily available precursors.

Unraveling two pathways for NHPI-mediated electrocatalytic oxidation reaction

Two pathways for N-hydroxyphthalimide (NHPI)-mediated electrocatalytic oxidation using phenylacetate derivatives as template substrates were first reported for benzylic C[sbnd]H oxidation to oxygenated and non-oxygenated products. DFT calculation indicates that the hydrogen-atom transfer (HAT) process between phthalimido-N-oxyl (PINO) and substrate is a rate-determined step. Aromatic α-keto esters and 2-((1,3-dioxoisoindolin-2-yl)oxy)-2-aryl acetate obtained by cross-coupling between benzylic radical and PINO can be selectively synthesized through controlling the concentration of PINO radical. This method provides a deep understanding for selective weak C[sbnd]H oxidation using NHPI as redox mediator.

Stereoselective Synthesis of Dihydrocoumarins via [1,2]-Phospha-Brook Rearrangement in Three-Component Coupling Reaction of α-Ketoesters, o-Quinone Methides, and Dialkyl Phosphites

A highly regio- and diastereoselective approach for the synthesis of phosphate substituted dihydrocoumarins via Br?nsted base catalyzed [1,2]-phospha-Brook rearrangement is reported. The two-step, one-pot Michael addition of α-phosphonyloxy enolates proceeds by coupling of dialkyl phosphite and α-ketoesters to o-quinone methides, followed by an intramolecular cyclization, providing 3,4-dihydrocoumarin frameworks.