34966-51-3

Basic information

• Product Name: ETHYL 2,4-DICHLOROBENZOYLFORMATE
• Synonyms: ETHYL 2,4-DICHLOROBENZOYLFORMATE
• CAS NO: 34966-51-3
• Molecular Formula: C₁₀H₈Cl₂O₃
• Molecular Weight: 247.08
• Mol File: 34966-51-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 346.4°C at 760 mmHg
• Flash Point: 147°C
• Appearance: /
• Density: 1.362g/cm³
• Vapor Pressure: 5.78E-05mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: ETHYL 2,4-DICHLOROBENZOYLFORMATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2,4-DICHLOROBENZOYLFORMATE(34966-51-3)
• EPA Substance Registry System: ETHYL 2,4-DICHLOROBENZOYLFORMATE(34966-51-3)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 34966-51-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8Cl2O3/c1-2-15-10(14)9(13)7-4-3-6(11)5-8(7)12/h3-5H,2H2,1H3

Upstream product

• 4755-77-5 Ethyl oxalyl chloride 
• 541-73-1 1,3-Dichlorobenzene 
• 41204-18-6 (2,4-dichloro-phenyl)-hydroxy-acetic acid ethyl ester 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 74-96-4 ethyl bromide 
• 29898-32-6 2,4-dichloro-1-iodo-benzene 
• 95-92-1 oxalic acid diethyl ester 
• 1193-72-2 1-bromo-2,4-dichlorobenzene 

Downstream Products

• 99360-95-9 dichloro-(2,4-dichloro-phenyl)-acetic acid ethyl ester 
• 33131-20-3 2-(2,4-Dichloro-phenyl)-3-methyl-but-2-enoic acid ethyl ester 
• 98556-50-4 dichloro-(2,4-dichloro-phenyl)-acetic acid 
• 33105-07-6 (E)-4-Bromo-2-(2,4-dichloro-phenyl)-3-methyl-but-2-enoic acid ethyl ester 

Relevant articles and documents

Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues

Dysregulation of the hedgehog (Hh) signaling pathway is associated with cancer occurrence and development in various malignancies. Previous structure-activity relationships (SAR) studies have provided potent Itraconazole (ITZ) analogues as Hh pathway antagonists. To further expand on our SAR for the ITZ scaffold, we synthesized and evaluated a series of compounds focused on replacing the triazole. Our results demonstrate that the triazole region is amenable to modification to a variety of different moieties; with a single methyl group representing the most favorable substituent. In addition, nonpolar substituents were more active than polar substituents. These SAR results provide valuable insight into the continued exploration of ITZ analogues as Hh pathway antagonists.

Diol compounds as intermediates for preparing antimycotic compounds

A compound of formula (II), wherein R1is chloro, fluoro or trifluoromethyl; R2is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis

Asymmetric hydrogenation of α-keto acid derivatives by rhodium-{amidophosphine-phosphinite} catalysts

The enantioselective hydrogenation of several α-keto esters (3a-f, 5a-j), α-keto amides (7a-e) and isatine derivatives (9a-d) with a set of four representative neutral homogeneous rhodium-amidophosphine-phosphinite catalysts has been investigated. Trifluoroacetate-Rh-AMPP catalytic precursors promoted the rapid, efficient synthesis of aliphatic α-hydroxy esters 4a-f in moderate to high enantioselectivities (66-95% eel, in contrast to most aromatic α-hydroxy esters 6a-j (8-81% eel. Best enantioselectivities for α-hydroxy amides 8a-e (85-95% eel and dioxindoIes 10a-d (80-94% eel were obtained with chloro-Rh-AMPP precursors. It is proposed that, contrary to α-keto amides, α-keto esters do not chelate onto the rhodium center and that, in such circumstances, the asymmetric induction is mainly controlled by the steric hindrance around the C=O function.