350489-40-6

Basic information

• Product Name: 2-CHLORO-5-(4-METHOXYPHENYL)-PYRIDINE
• Synonyms: 2-CHLORO-5-(4-METHOXYPHENYL)-PYRIDINE
• CAS NO: 350489-40-6
• Molecular Formula: C₁₂H₁₀ClNO
• Molecular Weight: 219.67
• Mol File: 350489-40-6.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-CHLORO-5-(4-METHOXYPHENYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-5-(4-METHOXYPHENYL)-PYRIDINE(350489-40-6)
• EPA Substance Registry System: 2-CHLORO-5-(4-METHOXYPHENYL)-PYRIDINE(350489-40-6)

Safety Data

• Hazardous Substances Data: 350489-40-6(Hazardous Substances Data)

Upstream product

• 53939-30-3 5-bromo-2-chloropyridine 
• 213596-33-9 2-(4-methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborolane 
• 69045-79-0 2-choro-5-iodopyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1072-97-5 5-bromo-2-pyridylamine 
• 696-62-8 para-iodoanisole 
• 41288-96-4 6-chloropyridine-3-ol 

Downstream Products

• 173960-47-9 5-(4''-methoxyphenyl)-2,2'-bipyridine 
• 943301-76-6 5-(4-hydroxyphenyl)-2,2'-bipyridine 
• 943301-79-9 5-heptyl-5'-[4-(trifluoromethylsulfonyl)phenyl]-2,2'-bipyridine 
• 1377269-09-4 3-(4-chloro-2-methoxyphenyl)-6-(4-methoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine 
• 1377269-52-7 4-chloro-2-methoxy-N-(5-(4-methoxyphenyl)pyridin-2-yl)-benzohydrazide 

Relevant articles and documents

N-Heterocyclic Carbene Ligand-Controlled Chemodivergent Suzuki-Miyaura Cross Coupling

Two N-heterocyclic carbene ligands provide orthogonal chemoselectivity during the Pd-catalyzed Suzuki-Miyaura (SM) cross-coupling of chloroaryl triflates. The use of SIPr [SIPr = 1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene] leads to selective cross-coupling at chloride, while the use of SIMes [SIMes = 1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidene] provides selective coupling at triflate. With most chloroaryl triflates and arylboronic acids, ligand-controlled selectivity is high (≥10:1). The scope of this methodology is significantly more general than previously reported methods for selective SM coupling of chloroaryl triflates using phosphine ligands. Density functional theory studies suggest that palladium's ligation state during oxidative addition is different with SIMes compared to SIPr.

3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF

Disclosed are 3-aryl-6-aryl-[1,2,4]triazolo[4,3-a]pyridines thereof, represented by the Formula (I) wherein Ar1, Ar2, R1-R3 are defined herein. Compounds having Formula (I) are inhibitors of cell proliferation.

Preparation of polyfunctional arylmagnesium, arylzinc, and benzylic zinc reagents by using magnesium in the presence of LiCl

The presence of LiCl considerably facilitates the insertion of magnesium into various aromatic and heterocyclic bromides. Several functional groups, such as -OBoc, -OTs, -Cl, -F, -CF3, -OMe, -NMe2, and -N 2NR2, are well tolerated. The presence of a cyano group leads in some cases to competitive reduction of the organic halide to the corresponding ArH compound. The presence of sensitive groups such as methyl or ethyl ester is tolerated upon in situ trapping of the intermediate magnesium reagent with ZnCl2. This method can also be applied to the preparation of functionalized benzylic zinc reagents from benzylic chlorides. In the case of di- or tribromoaryl derivatives, directing groups such as -OPiv, -OTs, -N2NR2, or -OAc orient the zinc insertion (Zn/LiCl) to the ortho-position, while the reaction with Mg/LiCl or Mg/LiCl/ZnCl 2 leads to regioselective insertion into the para-carbon-bromine bond. Large-scale experiments (20-100 mmol) for all of the metalation procedures are described.