351003-48-0

Basic information

• Product Name: 3-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE
• Synonyms: 3-CHLORO-2-FLUOROBEN;3-Chloro-2-fluorobenzenesulfonyl chloride 97%;BUTTPARK 89\07-35;3-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE;3-CHLORO-2-FLUOROBENZENESULPHONYL CHLORIDE;3-CHLORO-2-FLUOROBENZENSULPHONYL CHLORIDE;Benzenesulfonyl chloride, 3-chloro-2-fluoro- (9CI);3-CHLORO-2-FLUOROBENZENSULFONYL CHLORIDE
• CAS NO: 351003-48-0
• Molecular Formula: C₆H₃Cl₂FO₂S
• Molecular Weight: 229.06
• EINECS: -0
• Product Categories: SULFONYLHALIDE;Aromatic Halides (substituted);Organic Building Blocks;Sulfonyl Halides;Sulfur Compounds
• Mol File: 351003-48-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 287℃
• Flash Point: >230 °F
• Appearance: /
• Density: 1.584 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00435mmHg at 25°C
• Refractive Index: n20/D 1.5540(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility: Hydrolyzes in water.
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: 3-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE(351003-48-0)
• EPA Substance Registry System: 3-CHLORO-2-FLUOROBENZENESULFONYL CHLORIDE(351003-48-0)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 351003-48-0(Hazardous Substances Data)

Usage

Uses

It is employed as a pharmaceutical intermediate.

InChI:InChI=1/C6H3Cl2FO2S/c7-4-2-1-3-5(6(4)9)12(8,10)11/h1-3H

Upstream product

• 2106-04-9 3-chloro-2-fluoroaniline 

Downstream Products

• 904679-63-6 methyl 2-{[(3-chloro-2-fluorophenyl)sulfonyl]amino}-5,6,7,8-tetrahydro-1-naphthalenecarboxylate 
• 1161943-96-9 3-Chloro-2-fluoro-N-(2-sulfamoylphenyl)benzenesulfonamide 
• 1215721-21-3 C₂₃H₂₂ClNO₄S 
• 1015168-91-8 N'-(3-chloro-2-fluorophenylsulfonyl)-N,4-diethyl-4,5-dihydro-1H-pyrazole-1-carboxamidine 
• 1392442-82-8 C₁₀H₉ClFNO₄S 
• 1392441-83-6 C₁₉H₂₀ClFN₄O₃S 
• 1392442-35-1 C₁₁H₁₁ClFNO₄S 
• 1380229-08-2 3-chloro-N-(2,4-difluoro-3-(3-(9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-yl)pyridin-2-ylamino)phenyl)-2-fluorobenzenesulfonamide 
• 351003-58-2 3-chloro-2-fluorobenzenesulfonamide 
• 1204573-07-8 3-chloro-2-cyclopropylaminobenzenesulfonamide 
• 1567836-55-8 3-chloro-2-fluoro-N-(5-(5-(2-methyl-1-oxoisoindolin-5-yl)thiophen-2-yl)pyridin-3-yl)benzene sulfonamide 

Relevant articles and documents

Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2 H -1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2 H -1,2,4-benzot

Two 4-ethyl-substituted pyridothiadiazine dioxides belonging to α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor positive allosteric modulators were cocrystallized with the GluA2 ligand binding domain in order to decipher the impact of