351343-80-1

Basic information

• Product Name: 1-(4-fluorophenyl)cyclohexane-1-carbaldehyde
• Synonyms: 1-(4-fluorophenyl)cyclohexane-1-carbaldehyde
• CAS NO: 351343-80-1
• Molecular Weight: 206.26
• Mol File: 351343-80-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-(4-fluorophenyl)cyclohexane-1-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-fluorophenyl)cyclohexane-1-carbaldehyde(351343-80-1)
• EPA Substance Registry System: 1-(4-fluorophenyl)cyclohexane-1-carbaldehyde(351343-80-1)

Safety Data

• Hazardous Substances Data: 351343-80-1(Hazardous Substances Data)

Upstream product

• 460-00-4 1-Bromo-4-fluorobenzene 
• 2043-61-0 cyclohexanecarbaldehyde 
• 459-22-3 4-fluorophenylacetonitrile 
• 111-24-0 1,5-dibromo-pentane 
• 71486-43-6 1-(4-fluorophenyl)cyclohexanecarbonitrile 

Downstream Products

• 1307809-84-2 1-((3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)methyl)azetidine-3-carboxylic acid 
• 1307812-85-6 3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-7-vinyl-4,5-dihydronaphtho[1,2-c]isoxazole 
• 1307812-86-7 1-(3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho[1,2-c]isoxazol-7-yl)ethane-1,2-diol 
• 1307812-87-8 3-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-4,5-dihydronaphtho[1,2-c]isoxazole-7-carbaldehyde 
• 1307810-01-0 1-((2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)methyl)azetidine-3-carboxylic acid 
• 351343-83-4 3-(1-(4-fluorophenyl)cyclohexyl)propanoic acid 
• 1307815-63-9 3-(1-(4-fluorophenyl)cyclohexyl)propanoyl chloride 
• 1307812-90-3 2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)-7-vinyl-4,5-dihydronaphtho[1,2-d]oxazole 
• 1307812-91-4 1-(2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazol-7-yl)ethane-1,2-diol 
• 1307812-92-5 2-(2-(1-(4-fluorophenyl)cyclohexyl)ethyl)naphtho[1,2-d]oxazole-7-carbaldehyde 
• 351343-82-3 ethyl 3-(1-(4-fluorophenyl)cyclohexyl)propanoate 
• 1307812-20-9 (E)-3-(1-(4-fluorophenyl)cyclohexyl)prop-2-en-1-ol 
• 1307812-21-0 (E)-4-(1-(4-fluorophenyl)cyclohexyl)but-3-enenitrile 
• 1307812-22-1 (E)-methyl 4-(1-(4-fluorophenyl)cyclohexyl)but-3-enoate 

Relevant articles and documents

Controlled Reduction of Nitriles by Sodium Hydride and Zinc Chloride

A new protocol for the controlled reduction of nitriles to aldehydes was developed using a combination of sodium hydride and zinc chloride. The iminyl zinc intermediates derived from aromatic nitriles could be further functionalized with allylmetal nucleophiles to afford homoallylamines. As the method allows the reduction of various aliphatic and aromatic nitriles with a concise procedure under milder reaction conditions and exhibits wide functional group compatibility, it is well suited for use in various opportunities in chemical synthesis.

Fe-catalyzed regiodivergent [1,2]-shift of α-aryl aldehydes

An Fe-catalyzed conversion of aldehydes to ketones via [1,2]-shift has been developed. This skeletal rearrangement shows a wide substrate scope and chemoselectivity profile while exhibiting an excellent [1,2]-aryl or [1,2]-alkyl shift selectivity that is easily switched by electronic effects.

TRICYCLIC HETEROCYCLIC COMPOUNDS

Disclosed are compounds of Formula (I) or stereoisomers or salts thereof, wherein: X1, X2, X3, W, Q1, Q2, and G2 are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.