35207-08-0Relevant articles and documents
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Prince,Orlando jun.
, p. 818 (1967)
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Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: Selective inhibitors of 11β-hydroxysteroid dehydrogenase type I
Xiang, Jason,Ipek, Manus,Suri, Vipin,Massefski, Walt,Pan, Ning,Ge, Ying,Tam, May,Xing, Yuzhe,Tobin, James F.,Xu, Xin,Tam, Steve
, p. 2865 - 2869 (2007/10/03)
The design, synthesis, and biological evaluation of arylsulfonamidooxazoles as 11β-HSD1 inhibitors and the serendipitous discovery of β-keto sulfones as potent 11β-HSD1 inhibitors are described here. These two classes of compounds are not active against 11β-HSD2 and therefore may have significant therapeutic potential for metabolic syndrome, type 2 diabetes and related metabolic dysfunctions.