35231-56-2

Basic information

• Product Name: 5-Hydroxy-2-methylpyrimidine
• Synonyms: 5-Hydroxy-2-methylpyrimidine;5-Pyrimidinol, 2-methyl- (9CI);2-methylpyrimidin-5-ol;2-METHYLPYRIMIDIN-5-OL,PURITY:95% MIN(HPLC);2-Methyl-5-hydroxypyrimidine;2-Methyl-5-pyrimidinol
• CAS NO: 35231-56-2
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11394
• Product Categories: PYRIMIDINE;Aromatics;Heterocycles;Intermediates;Heterocycle-Pyrimidine series
• Mol File: 35231-56-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 175-179℃
• Boiling Point: 208℃
• Flash Point: 80℃
• Appearance: /
• Density: 1.215
• Vapor Pressure: 0.148mmHg at 25°C
• Refractive Index: 1.556
• Storage Temp.: 2-8°C
• PKA: 6.92±0.23(Predicted)
• CAS DataBase Reference: 5-Hydroxy-2-methylpyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxy-2-methylpyrimidine(35231-56-2)
• EPA Substance Registry System: 5-Hydroxy-2-methylpyrimidine(35231-56-2)

Safety Data

• Hazardous Substances Data: 35231-56-2(Hazardous Substances Data)

Usage

Uses

Pyrimidinyl derivative as insecticide intermediate.

InChI:InChI=1/C5H6N2O/c1-4-6-2-5(8)3-7-4/h2-3,8H,1H3

Upstream product

• 7752-78-5 5-bromo-2-methylpyrimidine 

Downstream Products

• 1581683-96-6 C₃₃H₃₉FN₈O₆ 

Relevant articles and documents

UV SPECTROSCOPIC STUDY OF THE ACID-BASE REACTIONS OF 3-HYDROXYPYRIDINES AND 5-HYDROXYPYRIMIDINES

The acid-base equilibrium behavior of alkyl(phenyl)-substituted 3-hydroxypyridines and 5-hydroxypyrimidines, and their dependence on pH values in aqueous solution, on the solvent, and on the phase composition, have been studied using UV spectroscopy.It has been found that in neutral aqueous solution all of the substituted 3-hydroxypyridines examined contain, in addition to the neutral form, a bipolar form, whose concentration depends on the nature and position of the substituent.In contrast, methyl substituted 5-hydroxypyrimidines form significant amounts of the bipolar form only in more acidic media.

ANTIVIRAL AGENT

The present invention provides an integrase inhibitor. The inventors have have found the following compound of formula (I) possessing an integrase inhibitory activity. (wherein, R C and R D taken together with the neighboring carbon atoms form a ring which may be a condensed ring, Y is hydroxy, mercapto or amino; Z is O, S or NH ; R A is a group shown by (wherein, C ring is N-containing aromatic heterocycle) or the like)