3526-45-2

Basic information

• Product Name: 2-[(PHENYLAMINO)METHYL]PHENOL
• Synonyms: 2-[(PHENYLAMINO)METHYL]PHENOL;N-(O-HYDROXY BENZYL)ANILINE;TIMTEC-BB SBB007834;o-Hydroxy-N-phenylbenzylamine;2-(Anilinomethyl)phenol;2-Hydroxybenzylphenylamine;N-(2-Hydroxybenzyl)aniline;N-Phenyl-2-hydroxybenzenemethanamine
• CAS NO: 3526-45-2
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• Mol File: 3526-45-2.mol
• Article Data: 67

Chemical Properties

• Boiling Point: 359.5°C at 760 mmHg
• Flash Point: 151.6°C
• Appearance: /
• Density: 1.185g/cm³
• Vapor Pressure: 1.14E-05mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 2-[(PHENYLAMINO)METHYL]PHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(PHENYLAMINO)METHYL]PHENOL(3526-45-2)
• EPA Substance Registry System: 2-[(PHENYLAMINO)METHYL]PHENOL(3526-45-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 3526-45-2(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 25, p. 813, 1995 DOI: 10.1080/00397919508013417

InChI:InChI=1/C13H13NO/c15-13-9-5-4-6-11(13)10-14-12-7-2-1-3-8-12/h1-9,14-15H,10H2

Upstream product

• 56-23-5 tetrachloromethane 
• 3155-16-6 diphenyl oxalate 
• 622-14-0 N,N'-diphenylmethylenediamine 
• 779-84-0 N-phenylsalicylaldimine 
• 20357-59-9 N-(salicylidene)aniline N-oxide 
• 13134-93-5 2-amino-2'-hydroxybenzophenone 
• 90-01-7 salicylic alcohol 
• 62-53-3 aniline 
• 5435-44-9 (E)-3-Ureido-but-2-enoic acid ethyl ester 
• 91-78-1 1,3,5-triphenylhexahydro-1,3,5-triazine 
• 108-95-2 phenol 
• 614-65-3 2-hydroxybenzaldehyde phenylhydrazone 
• 141-52-6 sodium ethanolate 
• 71-43-2 benzene 

Downstream Products

• 51287-17-3 3-phenyl-3,4-dihydro-2H-1,3-benzoxazine 
• 101602-51-1 N-[2-(2-dimethylamino-ethoxy)-benzyl]-aniline 
• 70301-60-9 3-chloro-5-phenyl-5,6-dihydro-benzo[f]pyridazino[3,4-b][1,4]oxazepine 
• 60398-98-3 3-phenyl-3,4-dihydro-benzo[e][1,2,3]oxathiazine 2-oxide 
• 139553-99-4 2,10-Diphenyl-9,10-dihydro-4-oxa-2,10-diaza-benzo[f]azulene-1,3-dione 
• 62-53-3 aniline 
• 13159-82-5 N-(4'-I-phenyl)-o-hydroxybenzylamine 
• 95-48-7 ortho-cresol 
• 30190-45-5 3,4-dihydro-3-phenyl-2H-benzo[e][1,3]oxazin-2-one 
• 779-84-0 salicylidene aniline 
• 139554-04-4 4'-[(2-Hydroxy-benzyl)-phenyl-amino]-1'-phenyl-2,3,4,5-tetrahydro-[1,3']bipyrrolyl-2',5'-dione 
• 36966-84-4 Benzol-anti-diazohydroxyd 
• 1054450-79-1 3-phenyl-3,4-dihydro-2H-benzo[e][1,3]oxazine-2,2-d₂ 
• 84821-36-3 acetato(2-phenylaminomethylphenolato)copper(II) 

Relevant articles and documents

A Facile Reduction Procedure for N,N′-bis[5-Substituted Salicylidene]-m/p-phenylenediamines with Sodium Borohydride-Silica Gel System

An easy approach involving sodium borohydride/silica gel system offers a fast method of reduction for N,N′-bis[5-substituted salicylidene] m/p-phenylenediamines to the corresponding amines with excellent yield. The observed formation of boron chelates in

Monitoring of reduction reaction of 2-((phenylimino)methyl)phenol compound with sodium borohydride in solution by infrared spectroscopy

In this study, an imine compound 2-((phenylimino)methyl)phenol was synthesized by the reaction of salicylaldehyde and aniline for in situ monitoring of reduction with sodium borohydride. The reduction of C = N double bond to C–N in solution was continuous

Sulfated polyborate: A dual catalyst for the reductive amination of aldehydes and ketones by NaBH4

An efficient, quick, and environment-friendly one-pot reductive amination of aldehydes or ketones was developed. In ethanol at 70 °C, a imination catalyzed by sulfated polyborate and further reduced by sodium borohydride yields various amines. The present method has many significant benefits, including a shorter reaction time, excellent yields, and a hassle-free, straightforward experimental process. The reaction has a wide range of applications due to its flexibility, including secondary amine for reductive amination.

Screening of simple carbohydrates as a renewable organocatalyst for the efficient construction of 1,3-benzoxazine scaffold

A convenient protocol for the two component preparation of 1,3-benzoxazines by using several protected and unprotected carbohydrate molecules as organocatalysts have been developed which is broadly applicable to condensation reaction between variety of Ma