35305-48-7

Basic information

• Product Name: 1-(4-methylbenzyl)-3-phenylthiourea
• Synonyms: thiourea, N-[(4-methylphenyl)methyl]-N'-phenyl-
• CAS NO: 35305-48-7
• Molecular Formula: C₁₅H₁₆N₂S
• Molecular Weight: 256.3659
• Mol File: 35305-48-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 393.2°C at 760 mmHg
• Flash Point: 191.6°C
• Density: 1.185g/cm³
• Vapor Pressure: 2.16E-06mmHg at 25°C
• Refractive Index: 1.669
• CAS DataBase Reference: 1-(4-methylbenzyl)-3-phenylthiourea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-methylbenzyl)-3-phenylthiourea(35305-48-7)
• EPA Substance Registry System: 1-(4-methylbenzyl)-3-phenylthiourea(35305-48-7)

Safety Data

• Hazardous Substances Data: 35305-48-7(Hazardous Substances Data)

Usage

Common use

Reagent in chemical research

Potential application

Anti-HIV drug targeting HIV integrase enzyme

Anti-cancer properties

Shown to inhibit the growth of cancer cells

Role in preventing drug resistance

Investigated for its potential to prevent the development of drug resistance in cancer cells

Medicinal and pharmaceutical potential

Significant potential due to diverse properties and potential therapeutic benefits

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 104-84-7 para-methylbenzylamine 
• 142010-50-2 3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl isocyanate 
• 92147-65-4 tert-butyl phenylcarbamodithioate 
• 103-70-8 Formanilid 
• 104-87-0 4-methyl-benzaldehyde 
• 103-85-5 monophenylthiourea 

Relevant articles and documents

Preparation method of thiourea alkylation derivative

The invention discloses a preparation method of a thiourea alkylation derivative, which comprises the following steps: stirring an aldehyde, N-arylthiourea, trichlorosilane and Lewis base in an organic solvent at a range of -10 DEG C to room temperature for reaction, and carrying out after-treatment to obtain the thiourea alkylation derivative, wherein the molar ratio of the aldehyde to the N-arylthiourea is 1:2 to 2:1, the molar ratio of the aldehyde to the Lewis base is 1:(0.01-0.20), the molar ratio of the aldehyde to trichlorosilane is 1:(1-2), R1 is a C1-C5 saturated alkyl group, or an unsubstituted or substituted aromatic ring, and R2 is H, an electron withdrawing substituent or an electron donating substituent. According to the method, trichlorosilane is catalyzed by the micromolecular Lewis base, reductive alkylation of thiourea is realized, synthesis can be realized by a one-pot method, and the method is simple to operate, short in reaction time, low in substrate toxicity, lowin cost, easy to obtain, mild in reaction condition and high in safety.

An isocyanide based multi-component reaction under catalyst- and solvent-free conditions for the synthesis of unsymmetrical thioureas

A new and efficient method for the synthesis of thiourea derivatives by a sequential one-pot, three-component reaction between aromatic isocyanides, amines, and 1,2-di-tert-butyldisulfane (DTBS) was developed and 27 different examples were synthesized in good to excellent yields. DTBS was identified as an effective sulfur surrogate without the use of both catalysts and solvents. This protocol does not employ any transition metal catalyst or special experimental setup.

Fluorous electrophilic scavengers for solution-phase parallel synthesis

A fluorous isatoic anhydride and isocyanate are synthesized and used as scavengers for amines in solution-phase parallel synthesis of urea, thiourea, and β-hydroxyamine analogs. The resulting fluorous derivatives are readily separated from the reaction mi