353497-17-3Relevant articles and documents
Strategies for large-scale synthesis of coelenterazine for in vivo applications
Shrestha, Tej B.,Troyer, Deryl L.,Bossmann, Stefan H.
, p. 646 - 652 (2014/03/21)
A new application of two Negishi-type coupling reactions for the synthesis of coelenterazine is reported. The synthesis of coelenterazine in high purity on a gram scale will enable numerous approaches to bioluminescence imaging and possibly photodynamic therapy of deep-seated tumors. Coelenterazine is the substrate for several luciferases, among them Gaussia luciferase (gLuc). This synthesis starts with pyrazin-2-amine and uses inexpensive starting materials and catalysts. Georg Thieme Verlag Stuttgart New York.