35351-20-3Relevant articles and documents
A 5-substituted phenylpropyl furan-2-carboxylic acid and its derivative synthesis method
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Paragraph 0051; 0052, (2016/11/21)
The invention discloses a synthesis method for 5-substituted benzofuran-2-carboxylic acid and the derivatives thereof. The synthesis method comprises the following steps of: 1) performing a chloromethylation reaction or a bromomethylation reaction on 4-substituted phenol to generate 2-halogenated methyl-4-substituted phenol; 2) reacting 2-halogenated methyl-4-substituted phenol with triphenylphosphine to generate 2-hydroxyl-5-substituted halogenated benzyltriphenyl phosphonium; 3) performing a ring-closing reaction on 2-hydroxyl-5-substituted halogenated benzyltriphenyl phosphonium and trichloroacetyl chloride in an alkaline condition to obtain 2-trichloromethyl-5-substituted benzofuran; and 4) performing alcoholysis on 2-trichloromethyl-5-substituted benzofuran in an acidic condition to obtain 5-substituted benzofuran-2-carboxylic ester, and then performing functional group conversion to obtain a series of derivatives. According to the synthesis method provided by the invention, cheap and easily-available raw materials are used, thus reducing production cost; and moreover, the synthesis method is simple and convenient in process, easy to enlarge, and high in implement value.
