35402-54-1

Basic information

• Product Name: 4-(2-ForMylaMino-phenyl)-4-oxo-butyric acid
• Synonyms: 4-(2-ForMylaMino-phenyl)-4-oxo-butyric acid;4-(2-ForMaMidophenyl)-4-oxobutanoic acid
• CAS NO: 35402-54-1
• Molecular Formula: C₁₁H₁₁NO₄
• Molecular Weight: 221.20934
• Mol File: 35402-54-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 524.567°C at 760 mmHg
• Flash Point: 271.049°C
• Appearance: /
• Density: 1.338g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.604
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-ForMylaMino-phenyl)-4-oxo-butyric acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-ForMylaMino-phenyl)-4-oxo-butyric acid(35402-54-1)
• EPA Substance Registry System: 4-(2-ForMylaMino-phenyl)-4-oxo-butyric acid(35402-54-1)

Safety Data

• Hazardous Substances Data: 35402-54-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H11NO4/c13-7-12-9-4-2-1-3-8(9)10(14)5-6-11(15)16/h1-4,7H,5-6H2,(H,12,13)(H,15,16)

Upstream product

• 830-96-6 Indole-3-propionic acid 

Downstream Products

• 35402-55-2 4-(2-aminophenyl)-4-oxobutanoic acid 

Relevant articles and documents

Indole-3-propionic acid has chemical chaperone activity and suppresses endoplasmic reticulum stress-induced neuronal cell death

Insoluble aggregated proteins are often associated with neurodegenerative diseases. Previously, we investigated chemical chaperones that prevent the aggregation of denatured proteins. Among these, 4-phenyl butyric acid (4-PBA) has well-documented chemical chaperone activity, but is required at doses that have multiple effects on cells, warranting further optimization of treatment regimens. In this study, we demonstrate chemical chaperone activities of the novel compound indole-3-propionic acid (IPA). Although it has already been reported that IPA prevents β-amyloid aggregation, herein we show that this compound suppresses aggregation of denatured proteins. Our experiments with a cell culture model of Parkinson's disease are the first to show that IPA prevents endoplasmic reticulum (ER) stress and thereby protects against neuronal cell death. We suggest that IPA has potential for the treatment of neurodegenerative diseases and other diseases for which ER stress has been implicated.