35410-28-7 Usage
Description
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate, also known as Prednisolone 21-Methanesulfonate, is a synthetic corticosteroid derivative of Prednisolone. It is metabolically interconvertible with prednisone and possesses potent anti-inflammatory and immunosuppressive properties. 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is characterized by its ability to modulate the immune system and reduce inflammation, making it a valuable pharmaceutical agent for various medical applications.
Uses
Used in Pharmaceutical Industry:
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is used as an anti-inflammatory and immunosuppressive agent for the treatment of various conditions, including autoimmune diseases, allergies, and inflammation-related disorders. Its potent anti-inflammatory effects help alleviate symptoms and reduce the severity of these conditions.
Used in Dermatology:
In the field of dermatology, 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is utilized as a topical treatment for various skin conditions, such as eczema, psoriasis, and dermatitis. Its ability to reduce inflammation and suppress the immune response helps to soothe irritated skin and promote healing.
Used in Ophthalmology:
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is also used in ophthalmology as an anti-inflammatory agent for the treatment of eye conditions, such as uveitis and other inflammatory eye disorders. Its potent anti-inflammatory properties help to reduce swelling and discomfort associated with these conditions.
Used in Respiratory Medicine:
In respiratory medicine, 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is employed as a treatment for chronic obstructive pulmonary disease (COPD) and other inflammatory lung conditions. Its anti-inflammatory and immunosuppressive effects help to reduce inflammation in the airways and improve lung function.
Used in Gastroenterology:
In the field of gastroenterology, 11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is used to treat inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis. Its ability to suppress the immune system and reduce inflammation helps to alleviate symptoms and promote healing in the gastrointestinal tract.
Used in Rheumatology:
11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-methanesulphonate is also used in rheumatology for the treatment of various autoimmune and inflammatory joint disorders, such as rheumatoid arthritis and lupus. Its potent anti-inflammatory and immunosuppressive properties help to reduce joint inflammation and alleviate pain associated with these conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 35410-28-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,1 and 0 respectively; the second part has 2 digits, 2 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 35410-28:
(7*3)+(6*5)+(5*4)+(4*1)+(3*0)+(2*2)+(1*8)=87
87 % 10 = 7
So 35410-28-7 is a valid CAS Registry Number.
InChI:InChI=1/C22H30O7S/c1-20-8-6-14(23)10-13(20)4-5-15-16-7-9-22(26,18(25)12-29-30(3,27)28)21(16,2)11-17(24)19(15)20/h6,8,10,15-17,19,24,26H,4-5,7,9,11-12H2,1-3H3/t15-,16-,17-,19+,20-,21-,22-/m0/s1
35410-28-7Relevant articles and documents
Synthesis of novel anti-inflammatory steroidal macrocycles using ring closing metathesis reaction
Biju, Purakkattle,Bitar, Rema,Lim, Yeon-Hee,Wang, Ying,Berlin, Michael,Aslanian, Robert,McCormick, Kevin
, p. 636 - 638 (2015)
A novel class of 13 and 16 membered steroidal macrocycles were synthesized by using ring closing metathesis reaction from the readily available anti-inflammatory steroids such as prednisolone, 6-methyl prednisolone, and 16-methyl prednisolone.
Steroidal C-21 mercapto derivatives as dissociated steroids: Discovery of an inhaled dissociated steroid
Biju, Purakkattle,McCormick, Kevin,Aslanian, Robert,Berlin, Michael,Solomon, Daniel,Chapman, Richard,McLeod, Robbie,Prelusky, Daniel,Eckel, Stephen,Kelly, George,Natiello, Michelle,House, Aileen,Fernandez, Xiomara,Bitar, Rema,Phillips, Jonathan,Anthes, John
scheme or table, p. 6343 - 6347 (2011/12/02)
A series of C-21 mercapto derivatives of hydrocortisone have been synthesized and evaluated in cell based transrepression and transactivation assays. The benzothiazole derivative, compound 6 not only showed a dissociated profile in vitro functional assays but also a pharmacological profile in a Brown-Norway rat therapeutic index model of asthma that dissociated side effects (thymolysis) while maintaining efficacy against pulmonary inflammation and lung function.