354112-08-6Relevant articles and documents
Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition
Reich, Siegfried H.,Sprengeler, Paul A.,Chiang, Gary G.,Appleman, James R.,Chen, Joan,Clarine, Jeff,Eam, Boreth,Ernst, Justin T.,Han, Qing,Goel, Vikas K.,Han, Edward Z. R.,Huang, Vera,Hung, Ivy N. J.,Jemison, Adrianna,Jessen, Katti A.,Molter, Jolene,Murphy, Douglas,Neal, Melissa,Parker, Gregory S.,Shaghafi, Michael,Sperry, Samuel,Staunton, Jocelyn,Stumpf, Craig R.,Thompson, Peggy A.,Tran, Chinh,Webber, Stephen E.,Wegerski, Christopher J.,Zheng, Hong,Webster, Kevin R.
, p. 3516 - 3540 (2018/05/01)
Dysregulated translation of mRNA plays a major role in tumorigenesis. Mitogen-activated protein kinase interacting kinases (MNK)1/2 are key regulators of mRNA translation integrating signals from oncogenic and immune signaling pathways through phosphoryla
ANTI-ANGIOGENESIS COMPOUND, INTERMEDIATE AND USE THEREOF
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Paragraph 0076; 0077, (2016/04/10)
Disclosed are an anti-abnormal proliferation of angiogenesis compound represented by formula I, use and intermediate thereof. The compound has good effect against abnormal proliferation of angiogenesis, and the activity of the compound is produced by inhibiting VEGFR2. The compound can be used for treating diseases, such as wet macular degeneration, inflammation, malignant tumor and the like, caused by abnormity of angiogenesis and protein kinases such as VEGFR2, FGFR2 and the like.
Α 7 as intranuclear hydroxynicotinic acetylcholine receptor quinuclidines compd.
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Paragraph 0653; 0654, (2018/10/03)
PROBLEM TO BE SOLVED: To provide ligands for the nicotinic α-7 receptor used for the treatment of various disorders of the central nervous system, especially affective and neurodegenerative disorders.SOLUTION: The disclosure provides compounds of the specified formula I, including their salts, and compositions and methods using the compounds.