35424-81-8 Usage
Description
H-[15N]TYR-OH, also known as L-Tyrosine-15N, is a labeled analogue of L-Tyrosine (T899975), which is one of the 22 proteinogenic amino acids used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is further converted to L-DOPA, which is then transformed into neurotransmitters such as dopamine, norepinephrine, and epinephrine. H-[15N]TYR-OH is a solid compound and is utilized in various applications due to its unique properties.
Uses
Used in Pharmaceutical Industry:
H-[15N]TYR-OH is used as a labeled compound for studying the metabolic pathways and functions of L-Tyrosine in the human body. The application reason is to understand the role of L-Tyrosine in the synthesis of neurotransmitters and its conversion from L-phenylalanine.
Used in Research and Development:
H-[15N]TYR-OH is used as a research tool for investigating the mechanisms of neurotransmitter synthesis and the role of L-Tyrosine in various biological processes. The application reason is to gain insights into the regulation of neurotransmitter levels and the potential therapeutic applications of modulating L-Tyrosine metabolism.
Used in Diagnostic Applications:
H-[15N]TYR-OH is used as a diagnostic marker for monitoring the levels of L-Tyrosine and its metabolites in biological samples. The application reason is to detect and diagnose conditions related to the dysregulation of neurotransmitter synthesis and to monitor the effectiveness of treatments targeting these pathways.
Used in Drug Development:
H-[15N]TYR-OH is used as a starting material or intermediate in the development of new drugs targeting L-Tyrosine metabolism and neurotransmitter synthesis. The application reason is to create novel therapeutic agents for the treatment of neurological disorders and other conditions related to neurotransmitter imbalances.
Used in Nutritional Supplements:
H-[15N]TYR-OH is used as an ingredient in nutritional supplements designed to support neurotransmitter synthesis and overall brain health. The application reason is to provide a labeled form of L-Tyrosine that can be easily studied and monitored for its effects on cognitive function and mood regulation.
Check Digit Verification of cas no
The CAS Registry Mumber 35424-81-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,4,2 and 4 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 35424-81:
(7*3)+(6*5)+(5*4)+(4*2)+(3*4)+(2*8)+(1*1)=108
108 % 10 = 8
So 35424-81-8 is a valid CAS Registry Number.
35424-81-8Relevant articles and documents
An Efficient Chemomicrobiological Synthesis of Stable Isotope-Labeled L-Tyrosine and L-Phenylalanine
Walker, T. E.,Matheny, C.,Storm, C. B.,Hayden, H.
, p. 1175 - 1179 (2007/10/02)
L-Tyrosine specifically labeled with 2H, 13C, 18O, or 15N has been synthesized by using a combination of organic synthetic methods and the β-tyrosinase enzyme activity of the bacterium Erwinia herbicola.The following L-tyrosine isotopomers were prepared: L-tyrosine from phenol and L-serine, L-tyrosine from phenol and L-serine, L-tyrosine from phenol and L-serine, L-tyrosine from ammonium sulfate, phenol, and pyruvate, and L-tyrosine from phenol and L-serine.The β-tyrosinase activitywas also used to prepare 2'-fluoro-L-tyrosine and 3'-fluoro-L-tyrosine from 3-fluorophenol and 2-fluorophenol, respectively.Phenol enriched with 13C was prepared by the condensation of acetone with nitromalonaldehyde, reduction of the resulting p-nitrophenol to p-aminophenol, and reductive removal of the nitrogen from the diazonium salt to form either - or phenol in a 40percent overall yield from acetone.The yields of L-tyrosine were typically around 90percent from labeled phenol.Labeled L-phenylalanine was chemically prepared from L-tyrosine in a 75percent overall yield.This was deemed the best approach to labeled L-phenylalanine, given the efficient method for preparing L-tyrosine from phenol.The approach to labeled L-phenylalanine represents a unique combination of chemical synthesis (phenol), biosynthesis (L-tyrosine), and finally chemical synthesis (L-phenylalanine).The chirality is introduced by the biochemical step, obviating the need for elaborate and inherently inefficient chiral manipulations.
