35474-99-8

Basic information

• Product Name: 1-MONOARACHIDIN
• Synonyms: EICSANOIN;5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID, 1-GLYCERYL ESTER;1-MONOARACHIDIN;1-ARACHIDONOYL GLYCEROL;1-AG;MONOARACHIDIN;MONOEICOSANOIN;1-arachidonylmonoglyceride
• CAS NO: 35474-99-8
• Molecular Formula: C₂₃H₃₈O₄
• Molecular Weight: 386.61
• Mol File: 35474-99-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 81.5 °C
• Boiling Point: 508.6 °C at 760 mmHg
• Flash Point: 163 °C
• Appearance: /
• Density: 0.992 g/cm³
• Vapor Pressure: 1.78E-12mmHg at 25°C
• Refractive Index: 1.507
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 13.15±0.20(Predicted)
• CAS DataBase Reference: 1-MONOARACHIDIN(CAS DataBase Reference)
• NIST Chemistry Reference: 1-MONOARACHIDIN(35474-99-8)
• EPA Substance Registry System: 1-MONOARACHIDIN(35474-99-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 35474-99-8(Hazardous Substances Data)

Usage

Description

1-MONOARACHIDIN, a derivative of 2-Arachidonoylglycerol (A765050), is a significant endocannabinoid that plays a crucial role in the endocannabinoid system. It possesses the ability to inhibit synaptic transmission through its action on presynaptic cannabinoid CB1 receptors, making it a promising candidate for various therapeutic applications.

Uses

Used in Pharmaceutical Industry:
1-MONOARACHIDIN is used as a therapeutic agent for managing various conditions related to the endocannabinoid system. Its ability to inhibit synaptic transmission via cannabinoid CB1 receptors makes it a potential candidate for treating neurological disorders, pain management, and other conditions influenced by the endocannabinoid system.
Used in Research Applications:
1-MONOARACHIDIN serves as an important research tool in studying the endocannabinoid system and its role in various physiological and pathological processes. It aids researchers in understanding the mechanisms of action, signaling pathways, and potential therapeutic targets within the system.
Used in Drug Development:
1-MONOARACHIDIN is utilized in the development of novel drugs targeting the endocannabinoid system. Its interaction with cannabinoid CB1 receptors provides insights into the design and synthesis of new drug candidates that can modulate the system for therapeutic benefits.

InChI:InChI=1/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-21-22(25)20-24/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-

Upstream product

• 53847-30-6 2-arachidonoyl glycerol 

Relevant articles and documents

Simplified chemical and radiochemical synthesis of 2-arachidonoyl-glycerol, an endogenous ligand of cannabinoid receptors

Endocannabinoids have emerged as a new class of lipid mediators, with manifold roles in the central nervous system and in the periphery. Several studies have identified 2-arachidonoyl-glycerol (2-AG) as a major endogenous agonist of cannabinoid receptors. Here, the chemical synthesis of 2-AG is reported, along with the synthesis of its tritium-labeled derivative. These unlabeled and radiolabeled compounds are suitable tools for unravelling some metabolic routes and biological activities of 2-AG in various cells and tissues.