35509-93-4

Basic information

• Product Name: Benzene, 1-(iodomethyl)-2-methyl-
• CAS NO: 35509-93-4
• Molecular Formula: C8H9I
• Molecular Weight: 232.064
• Mol File: 35509-93-4.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1-(iodomethyl)-2-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-(iodomethyl)-2-methyl-(35509-93-4)
• EPA Substance Registry System: Benzene, 1-(iodomethyl)-2-methyl-(35509-93-4)

Safety Data

• Hazardous Substances Data: 35509-93-4(Hazardous Substances Data)

Upstream product

• 89-95-2 2-methyl-benzyl alcohol 
• 95-47-6 o-xylene 
• 118-90-1 ortho-methylbenzoic acid 
• 932-31-0 ortho-tolylmagnesium bromide 
• 1950-78-3 p-toluenesulfonyl iodide 
• 89-92-9 2-methylbenzyl bromide 
• 16814-26-9 bis(2-methylbenzyl) ether 
• 529-20-4 2-methylphenyl aldehyde 

Downstream Products

• 38418-11-0 2-methylbenzyl benzoate 
• 1358991-64-6 C₂₃H₂₆O₄ 
• 1070313-34-6 2-(benzofuran-3-yl)-N-furan-2-yl-N-(2-methylbenzyl)acetamide 
• 1006034-36-1 2-chloro-4-{[(3S)-1-methyl-5-oxo-3-pyrrolidinyl][(2-methylphenyl)methyl]amino}benzonitrile 

Relevant articles and documents

Conversion of Aryl Aldehydes to Benzyl Iodides and Diarylmethanes by H3PO3/I2

For the first time, H3PO3 was used as both the reducing reagent and the promotor in the reductive benzylation reactions with aryl aldehydes. By using a H3PO3/I2 combination, various aromatic aldehydes underwent iodination reactions and Friedel-Crafts type reactions with arenes via benzyl iodide intermediates, readily producing benzyl iodides and diarylmethanes in good yields. Intramolecular cyclization reactions also took place, giving the corresponding cyclic compounds. This new strategy features easy-handling, low-cost, and metal-free conditions.

Iminophosphorane-mediated regioselective umpolung alkylation reaction of α-iminoesters

Umpolung reactions of imines, especially the asymmetric reactions, have been extensively studied as they provide access to important chiral amines in an efficient manner. The reactions studied range from simple Michael reactions to several kinds of other reactions such as the aza-benzoin reaction, aza-Stetter reaction, addition with MBH carbonate, and Ir-catalysed allylation. Herein, we report the first umpolung alkylation reaction of α-iminoesters with alkyl halides mediated by iminophosphorane as an organic superbase. The desired products were obtained in up to 82% yield with almost perfect regioselectivities. The key to the regioselectivity of this reaction was the use of 4-trifluoromethyl benzyl imines as a substrate. The products were successfully derivatised into the more functionalised molecules in good yields.

Preparation method of benzyl iodide and derivatives thereof

The invention discloses a preparation method of benzyl iodide and derivatives thereof. The preparation method comprises the following steps: under the reduction action of sodium borohydride, a benzylalcohol compound shown as a formula I reacts with elemental iodine to obtain benzyl iodide shown as a formula II and derivatives thereof; in the formula I and the formula II, R represents one or moresubstituents on a benzene ring and is selected from at least one of aryl, substituted or unsubstituted alkyl, halogen and nitro. The preparation method of benzyl iodide and derivatives thereof is scientific and reasonable, sodium borohydride which is mild in reactivity, low in price and easily available is used as a reducing agent, and elemental iodine is convenient and easily available; in addition, the preparation method has the characteristics of simplicity and convenience in operation, high synthesis yield, easiness in product purification, environmental friendliness and the like.