3558-32-5

Basic information

• Product Name: (R/S)-2-AMINO-5-METHYLHEXANOIC ACID
• Synonyms: (R/S)-2-AMINO-5-METHYLHEXANOIC ACID;5-METHYL-NORLEUCINE;Nsc20145;Norleucine, 5-Methyl-;DL-2-Amino-5-methylhexanoic acid
• CAS NO: 3558-32-5
• Molecular Formula: C7H15NO2
• Molecular Weight: 145.2
• Mol File: 3558-32-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 280 °C (sublm)
• Boiling Point: 243℃
• Flash Point: 101℃
• Appearance: /
• Density: 1.014
• PKA: 2.55±0.28(Predicted)
• CAS DataBase Reference: (R/S)-2-AMINO-5-METHYLHEXANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (R/S)-2-AMINO-5-METHYLHEXANOIC ACID(3558-32-5)
• EPA Substance Registry System: (R/S)-2-AMINO-5-METHYLHEXANOIC ACID(3558-32-5)

Safety Data

• Hazardous Substances Data: 3558-32-5(Hazardous Substances Data)

Usage

General Description

(R/S)-2-AMINO-5-METHYLHEXANOIC ACID, also known as leucine, is an essential amino acid that plays a crucial role in protein synthesis and muscle repair. It is one of the three branched-chain amino acids (BCAAs) and is particularly important for maintaining muscle mass and promoting recovery after exercise. It is also involved in the regulation of blood sugar levels and the growth and repair of muscle tissue. Leucine is commonly found in protein-rich foods such as meat, fish, and dairy products, and is also available as a dietary supplement for athletes and individuals looking to support muscle growth and recovery.

Upstream product

• 616-87-5 isoamylmalonic acid 
• 4431-59-8 2-isopentyl-malonamic acid 
• 872270-43-4 isopentyl-malonic acid-monoazide 
• 109186-96-1 2-acetylamino-2-cyano-5-methyl-hexanoic acid ethyl ester 
• 2769-72-4 tert-Butyl isocyanoacetate 
• 107-82-4 i-pentyl bromide 
• 56256-78-1 2-bromo-5-methyl-hexanoic acid 
• 151-50-8 potassium cyanide 
• 1119-16-0 isocaproic aldehyde 
• 541-28-6 isopentyl iodide 

Downstream Products

• 88824-61-7 2-Amino-5-methyl-hexanoic acid methyl ester 
• 5440-33-5 2-acetamido-5-methylhexanoic acid 
• 127862-71-9 2-Benzyloxycarbonylamino-5-methyl-hexanoic acid 2,2,2-trifluoro-ethyl ester 
• 31872-98-7 L-2-amino-5-methyl hexanoic acid 
• 117560-22-2 (S)-2-Amino-5-methyl-hexanoic acid benzyl ester; compound with toluene-4-sulfonic acid 

Relevant articles and documents

Studies on Angiotensin Converting Enzyme Inhibitors. 4. Synthesis and Angiotensin Converting Enzyme Inhibitory Activities of 3-Acyl-1-alkyl-2-oxoimidazolidine-4-carboxylic Acid Derivatives

(4S)-1-Alkyl-3-acyl>-2-oxoimidazolidine-4-carboxylic acid derivatives (3) were prepared by two methods.Their angiotensin converting enzyme (ACE) inhibitory activities and antihypertensive effects were evaluated, and the structure-activity relationships were discussed.The dicarboxylic acids 3a-n possessing S,S,S configuration showed potent in vitro ACE inhibitory activities with IC 50 values of 1.1x10-8-1.5x10-9 M.The most potent compound in this series, monoester 3p, had an ID 50 value of 0.24 mg/kg, po for inhibition of angiotensin I induced pressor response in normotensive rats and produced a dose-dependent decrease in systolic blood pressure of spontaneously hypertensive rats (SHRs) at doses of 1-10 mg/kg, po.

Synthesis of L α amino acids structurally related to isoleucine

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