35594-15-1Relevant articles and documents
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Pollet,P.,Gelin,S.
, p. 1453 - 1455 (1978)
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METHYL(R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-4,5,6, 7-TETRAHYDRO-1H-CYCLOPENTA[B]PYRIDINE-3-CARBOXYLATE AND METHYL(R)-2-(FLUOROMETHYL)-5-OXO-4-PHENYL-1,4,5,7-TETRAHYDROFURO[3,4-B]PYRIDINE-3-CARBOXYLATE USED AS ACTIVATORS OF CAV1.2
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Page/Page column 31, (2022/01/05)
The invention relates to a compound according to formula (I) or a pharmaceutically acceptable salt thereof used as activators of CaV1.2 for the treatment of schizophrenia, bipolar disorder, major depressive disorder, ADHD, Phelan-McDermid syndrome, autism spectrum disorder, multiple sclerosis, frontotemporal dementia, Alzheimer's disease, Brugada syndrome, short QT syndrome or early repolarization syndrome.
Synthesis of γ-acetoxy β-keto esters through regioselective hydration of γ-acetoxy-α,β-alkynoates
Pradhan, Tapas R.,Mendhekar, Kishor L.,Mohapatra, Debendra K.
, p. 5517 - 5531 (2015/06/16)
The Au(I)-catalyzed regioselective hydration of γ-acetoxy-α,β-acetylinic ester by the assistance of a neighboring carbonyl group has been developed. Varieties of simple primary, secondary, and tertiary γ-acetoxy-α,β-acetylinic esters, even those bearing sensitive functional group in the remote reaction sites, are selectively hydrated to the corresponding β-keto esters. The reaction tolerates a wide variety of other carboxylates, such as benzoates, propionates, acrylates, and pivalates, including chiral carboxylates with retention of the configuration. The broad substrate scope, including the derivatization of complex natural products and neutral and open air conditions, makes this atom economical approach very practical. 18O labeling experiments disclose that the oxygen transposition occurs from the carboxylate group to the triple bond, not from water.