356531-67-4 Usage
Description
N-(4-FLUOROBENZYL)CYCLOHEXANAMINE is an organic compound with the molecular structure featuring a fluorobenzyl group attached to a cyclohexanamine core. N-(4-FLUOROBENZYL)CYCLOHEXANAMINE is known for its unique chemical properties and reactivity, making it a valuable component in various chemical reactions and applications.
Uses
Used in Chemical Synthesis:
N-(4-FLUOROBENZYL)CYCLOHEXANAMINE is used as a reagent in the chemoselective reduction of secondary amides and lactams to amines. This application takes advantage of its compatibility with the Tf2O-NaBH4 or Cp2ZrHCl-NaBH4 system, which allows for the selective transformation of target molecules without affecting other functional groups present in the molecule.
In the Pharmaceutical Industry:
N-(4-FLUOROBENZYL)CYCLOHEXANAMINE is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity enable the development of new drugs with potential applications in treating a range of medical conditions.
In the Chemical Research Industry:
N-(4-FLUOROBENZYL)CYCLOHEXANAMINE is also utilized in academic and industrial research settings for the development of new chemical methodologies and the exploration of novel reaction mechanisms. Its versatility in chemical reactions makes it a valuable tool for advancing the field of organic chemistry.
In the Material Science Industry:
N-(4-FLUOROBENZYL)CYCLOHEXANAMINE can be employed in the development of new materials with specific properties, such as improved stability, reactivity, or selectivity. Its incorporation into polymers or other materials can lead to enhanced performance in various applications, including coatings, adhesives, and catalysts.
Check Digit Verification of cas no
The CAS Registry Mumber 356531-67-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,6,5,3 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 356531-67:
(8*3)+(7*5)+(6*6)+(5*5)+(4*3)+(3*1)+(2*6)+(1*7)=154
154 % 10 = 4
So 356531-67-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H18FN/c14-12-8-6-11(7-9-12)10-15-13-4-2-1-3-5-13/h6-9,13,15H,1-5,10H2
356531-67-4Relevant articles and documents
H2 Activation by Non-Transition-Metal Systems: Hydrogenation of Aldimines and Ketimines with LiN(SiMe3)2
Elliott, Daniel C.,Marti, Alex,Mauleón, Pablo,Pfaltz, Andreas
supporting information, p. 1918 - 1922 (2019/01/16)
In recent years, H2 activation at non-transition-metal centers has met with increasing attention. Here, a system in which H2 is activated and transferred to aldimines and ketimines using substoichiometric amounts of lithium bis(trimethylsilyl)amide is reported. Notably, the reaction tolerates the presence of acidic protons in the α-position. Mechanistic investigations indicated that the reaction proceeds via a lithium hydride intermediate as the actual reductant.
An efficient palladium-catalyzed N-alkylation of amines using primary and secondary alcohols
Dang, Tuan Thanh,Ramalingam, Balamurugan,Shan, Siah Pei,Seayad, Abdul Majeed
, p. 2536 - 2540 (2013/11/19)
PdCl2 in the presence of dppe or Xantphos(t-Bu) as the ligand is found to be an efficient catalyst for the N-alkylation of various primary and cyclic secondary amines using primary alcohols at 90-130 C under neat conditions. Interestingly, good to excellent yields were achieved when more challenging secondary alcohols were used as alkylating agents at 130-150 C. The reaction could be easily scaled up, as demonstrated for a 10 mmol scale achieving yields up to 90% with a TON of 900.
Structure-activity relationships of small molecule inhibitors of RAGE-Aβ binding
Ross, Nathan T.,Deane, Rashid,Perry, Sheldon,Miller, Benjamin L.
, p. 7653 - 7658 (2013/08/23)
The Receptor for Advanced Glycation Endproducts ('RAGE') mediates transport of amyloid-β peptide (Aβ) into the brain, and is therefore an important target for the development of therapeutic agents for Alzheimer's disease. We describe structure-activity relationships for inhibition of RAGE-Aβ binding, derived from the analysis of a library of tertiary amides.
