356561-08-5

Basic information

• Product Name: 5-IODO-4-METHYL-PYRIDIN-2-YLAMINE
• Synonyms: 2-AMINO-5-IODO-4-METHYLPYRIDINE;5-IODO-4-METHYL-PYRIDIN-2-YLAMINE;5-IODO-4-METHYLPYRIDIN-2-AMINE;2-PyridinaMine, 5-iodo-4-Methyl-
• CAS NO: 356561-08-5
• Molecular Formula: C₆H₇IN₂
• Molecular Weight: 234.04
• Product Categories: Heterocyclic Compounds;Pyridines
• Mol File: 356561-08-5.mol
• Article Data: 9

Chemical Properties

• Melting Point: 117.3-118.0°C
• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: /
• Density: 1.898 g/cm³
• Vapor Pressure: 0.000712mmHg at 25°C
• Refractive Index: 1.674
• Storage Temp.: 2-8°C(protect from light)
• Sensitive: Light Sensitive
• CAS DataBase Reference: 5-IODO-4-METHYL-PYRIDIN-2-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-IODO-4-METHYL-PYRIDIN-2-YLAMINE(356561-08-5)
• EPA Substance Registry System: 5-IODO-4-METHYL-PYRIDIN-2-YLAMINE(356561-08-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-41
• RIDADR: UN 2811 6.1 / PGIII
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 356561-08-5(Hazardous Substances Data)

Usage

General Description

5-Iodo-4-methyl-pyridin-2-ylamine is a chemical compound, categorized under the class of organic compounds known as pyridinylamines. It is also known by its systematic name of 2-Amino-4-methyl-5-iodopyridine. The molecular formula of this compound is C6H6IN3. Fundamentally, the structure of this chemical compound consists of a pyridine ring, substituted with an iodine atom on one carbon and an amino and a methyl group on others. This product, represented by the CAS number 84905-80-6 is substantially used in the field of organic synthesis, pharmaceuticals, agrochemicals, and dyestuffs. Its properties and potential uses in these industries depend on its physicochemical attributes.

InChI:InChI=1/C6H7IN2/c1-4-2-6(8)9-3-5(4)7/h2-3H,1H3,(H2,8,9)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 

Downstream Products

• 550347-54-1 2-chloro-5-iodo-4-methylpyridine 
• 1262336-89-9 4-methyl-5-iodopyridin-2-yl 4-methylbenzenesulfonate 
• 1575831-12-7 1-(6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine]-1-yl)-2-(methylsulfonyl)ethanone 
• 1575837-05-6 tert-butyl 6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine]-1-carboxylate 
• 1575837-07-8 6'-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-1'H-spiro[azetidine-3,3'-furo[3,4-c]pyridine] trifluoroacetic acid salt 

Relevant articles and documents

Synthesis of bridged analogs of epibatidine. 3-Chloro-5,7,8,9,9a,10-hexahydro-7,10-methanopyrrolo[1,2-b]-2,6-naphthyridine and 2-chloro-5,5a,6,7,8,10-hexahydro-5,8-methanopyrrolo[2,1-b]-1,7-naphthyridine

The synthesis of conformationally locked analogs of epibatidine are described in which the key step is an intramolecular reductive palladium-catalyzed Heck-type coupling.

Remarkable switch in the regiochemistry of the iodination of anilines by N-iodosuccinimide: Synthesis of 1,2-dichloro-3,4-diiodobenzene

Direct iodination of anilines by NIS in polar solvents (such as DMSO) affords p-iodinated products with up to >99% regioselectivity. Switching to less polar solvents (such as benzene) in the presence of AcOH inverts this outcome toward dramatically increased or preferential generation of the o-isomers, also with up to >99% regioselectivity. This finding was exploited in the synthesis of 1,2-dichloro-3,4-diiodobenzene. Georg Thieme Verlag Stuttgart - New York.

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.