356566-57-9

Basic information

• Product Name: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid
• Synonyms: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid;6-Methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid
• CAS NO: 356566-57-9
• Molecular Formula: C₁₂H₁₁N₃O₅
• Molecular Weight: 277.23
• Mol File: 356566-57-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 489.5°C at 760 mmHg
• Flash Point: 249.8°C
• Appearance: /
• Density: 1.439g/cm³
• Vapor Pressure: 2.14E-10mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid(356566-57-9)
• EPA Substance Registry System: 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid(356566-57-9)

Safety Data

• Hazardous Substances Data: 356566-57-9(Hazardous Substances Data)

Usage

General Description

1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid is a chemical compound with a long and complicated name. 1,2,3,4-Tetrahydro-6-methyl-4-(4-nitrophenyl)-2-oxo-5-pyrimidinecarboxylic acid is a pyrimidine derivative with a nitrophenyl group and a carboxylic acid group, making it a potentially useful molecule for pharmaceutical or chemical research. The presence of the nitrophenyl group suggests that it may have some kind of pharmacological activity, possibly as a drug or as a precursor to a drug. The presence of the carboxylic acid group also suggests that this compound may have some potential for binding to proteins or other biomolecules. Overall, this compound is likely of interest to researchers in the pharmaceutical or chemical industries for its potential therapeutic or industrial applications.

InChI:InChI=1/C12H11N3O5/c1-6-9(11(16)17)10(14-12(18)13-6)7-2-4-8(5-3-7)15(19)20/h2-5,10H,1H3,(H,16,17)(H2,13,14,18)

Upstream product

• 674-82-8 4-methyleneoxetan-2-one 
• 555-16-8 4-nitrobenzaldehdye 
• 57-13-6 urea 
• 2440-60-0 2-methyl-isourea 
• 898798-67-9 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-cyano-ethyl ester 
• 205999-89-9 methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 541-50-4 2-acetoacetic acid 

Downstream Products

• 205999-89-9 methyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 123371-45-9 ethyl 6-methyl-4-(4-nitrophenyl)-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate 
• 295344-04-6 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid 2-ethylsulfanyl-ethyl ester 
• 296267-03-3 6-methyl-4-(4-nitro-phenyl)-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid cyclopentyl ester 

Relevant articles and documents

Synthesis method of 3,4-dihydropyrimidin-2-ketone compounds catalyzed by ionic liquid at room temperature

The present invention discloses a synthesis method of 3,4-dihydropyrimidin-2-ketone compounds catalyzed by ionic liquid at room temperature. Key technology is as follows: nano-silicon-loaded bronsted acid functional group ionic liquid is used as a catalys

Solid-Phase Synthesis of Dihydropyrimidones via N-Acyliminium Ion-Based α-Ureidoalkylations

The synthesis of 4-aryl-2-(thioxo)oxo-3,4-dihydropyrimidine-5-carboxylic acids is reported using two orthogonal solid-phase variations of the Biginelli condensation. In the first method, polymer-bound β-ketoesters are treated with aromatic aldehydes and urea under acidic conditions. The transient N-acyliminium ion that is initially formed from the aldehyde and urea precursors, is then intercepted by the resin-bound β-ketoesters. In an alternative approach, resin-bound β-ketoesters are condensed with aldehydes and O-methylisourea under basic conditions. Both orthogonal condensation procedures provide fair to excellent overall yields of the desired target structures.