356566-58-0 Usage
General Description
4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic acid is a chemical compound that belongs to the class of pyrimidine carboxylic acids. It is composed of a 6-membered ring containing a pyrimidine-2,4(1H,3H)-dione structure with a substituted fluorophenyl group at the 4th position and a methyl group at the 6th position. 4-(3,4-Difluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylic has potential biological activity and is being studied for its potential pharmaceutical applications. Its molecular structure makes it a promising candidate for further research in drug development and medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 356566-58-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,5,6,5,6 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 356566-58:
(8*3)+(7*5)+(6*6)+(5*5)+(4*6)+(3*6)+(2*5)+(1*8)=180
180 % 10 = 0
So 356566-58-0 is a valid CAS Registry Number.
356566-58-0Relevant articles and documents
Solid-Phase Synthesis of Dihydropyrimidones via N-Acyliminium Ion-Based α-Ureidoalkylations
Valverde, Maria Garcia,Dallinger, Doris,Kappe, C. Oliver
, p. 741 - 744 (2007/10/03)
The synthesis of 4-aryl-2-(thioxo)oxo-3,4-dihydropyrimidine-5-carboxylic acids is reported using two orthogonal solid-phase variations of the Biginelli condensation. In the first method, polymer-bound β-ketoesters are treated with aromatic aldehydes and urea under acidic conditions. The transient N-acyliminium ion that is initially formed from the aldehyde and urea precursors, is then intercepted by the resin-bound β-ketoesters. In an alternative approach, resin-bound β-ketoesters are condensed with aldehydes and O-methylisourea under basic conditions. Both orthogonal condensation procedures provide fair to excellent overall yields of the desired target structures.
