35664-99-4

Basic information

• Product Name: Cycloheptanecarbonyl chloride, 1-methyl- (9CI)
• Synonyms: Cycloheptanecarbonyl chloride, 1-methyl- (9CI)
• CAS NO: 35664-99-4
• Molecular Formula: C9H15ClO
• Molecular Weight: 174.6678
• Product Categories: ACIDHALIDE
• Mol File: 35664-99-4.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cycloheptanecarbonyl chloride, 1-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cycloheptanecarbonyl chloride, 1-methyl- (9CI)(35664-99-4)
• EPA Substance Registry System: Cycloheptanecarbonyl chloride, 1-methyl- (9CI)(35664-99-4)

Safety Data

• Hazardous Substances Data: 35664-99-4(Hazardous Substances Data)

Upstream product

• 35664-93-8 1-methyl-cycloheptanecarboxylic acid 
• 20043-64-5 (2-Methylcycloheptan-1-on-2-yl)-carbonsaeureethylester 
• 82322-90-5 ethyl 1-methyl-cycloheptanecarboxylate 
• 82322-89-2 ethyl 1-methyl-2-oxocycloheptanecarboxylate ethylene thioketal 
• 32730-85-1 cycloheptanecarbonitrile 
• 35664-87-0 1-Methylcycloheptacarbonitrile 
• 60433-00-3 methyl cycloheptanecarboxylate 
• 7362-77-8 C₁₀H₁₈O₂ 

Downstream Products

• 1534433-45-8 1-(4-methoxybenzyl)-N-(quinolin-8-yl)cycloheptanecarboxamide 
• 1534433-46-9 1-(4-methoxybenzyl)-2-(4-methoxyphenyl)-N-(quinolin-8-yl)cycloheptanecarboxamide 

Relevant articles and documents

Nickel-Catalyzed Aminoxylation of Inert Aliphatic C(sp3)-H Bonds with Stable Nitroxyl Radicals under Air: One-Pot Route to α-Formyl Acid Derivatives

Nickel-catalyzed aminoxylation of an unactivated C(sp3)-H bond with a stable nitroxyl radical has been accomplished for the first time to offer various N-alkoxyamine derivatives, which further enables a one-pot approach to α-formyl acid derivatives. The aminoxylation process reported also provides direct evidence for the oxidative addition of a cyclometallic intermediate with a free radical, which is helpful for the reaction-mechanism study in transition-metal-catalyzed functionalization of inert C(sp3)-H bonds.

Palladium(0)/PAr3-catalyzed intermolecular amination of C(sp3)-H bonds: Synthesis of β-amino acids

An intermolecular C(sp3)-H amination using a Pd0/PAr3 catalyst was developed. The reaction begins with oxidative addition of R2N-OBz to a Pd0/PAr3 catalyst and subsequent cleavage of a C(sp3)-H bond by the generated Pd-NR2 intermediate. The catalytic cycle proceeds without the need for external oxidants in a similar manner to the extensively studied palladium(0)-catalyzed C-H arylation reactions. The electron-deficient triarylphosphine ligand is crucial for this C(sp3)-H amination reaction to occur.

Nickel-catalyzed site-selective alkylation of unactivated C(sp 3)-H bonds

The direct alkylation of unactivated sp3 C-H bonds of aliphatic amides was achieved via nickel catalysis with the assist of a bidentate directing group. The reaction favors the C-H bonds of methyl groups over the methylene C-H bonds and tolerates various functional groups. Moreover, this reaction shows a predominant preference for sp3 C-H bonds of methyl groups via a five-membered ring intermediate over the sp2 C-H bonds of arenes in the cyclometalation step.