35675-44-6

Basic information

• Product Name: P-TOLYL-ACETYL CHLORIDE
• Synonyms: P-TOLYL-ACETYL CHLORIDE;2-(4-Methylphenyl)acetyl chloride
• CAS NO: 35675-44-6
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Mol File: 35675-44-6.mol
• Article Data: 70

Chemical Properties

• Boiling Point: 115℃/7.5mm
• Flash Point: 102.3°C
• Appearance: Pink/Liquid
• Density: 1.146g/cm³
• Vapor Pressure: 0.0388mmHg at 25°C
• Refractive Index: 1.531
• Sensitive: Moisture Sensitive
• CAS DataBase Reference: P-TOLYL-ACETYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: P-TOLYL-ACETYL CHLORIDE(35675-44-6)
• EPA Substance Registry System: P-TOLYL-ACETYL CHLORIDE(35675-44-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: 8
• Hazardous Substances Data: 35675-44-6(Hazardous Substances Data)

Usage

General Description

P-Tolyl-acetyl chloride is an organic compound with the chemical formula C9H9ClO. It is a colorless to pale yellow liquid that is commonly used as a chemical intermediate in the production of pharmaceuticals and agrochemicals. P-Tolyl-acetyl chloride is primarily used in the synthesis of various pharmaceutical drugs, especially those related to the treatment of central nervous system disorders. It is also utilized in the development of herbicides and insecticides. Additionally, p-tolyl-acetyl chloride is a valuable reagent in organic chemistry for the acylation of amines, alcohols, and phenols, as well as in the preparation of other functionalized compounds. Due to its versatile applications, p-tolyl-acetyl chloride is an important chemical in the pharmaceutical and agrochemical industries.

InChI:InChI=1/C9H9ClO/c1-7-2-4-8(5-3-7)6-9(10)11/h2-5H,6H2,1H3

Upstream product

• 622-47-9 4-tolylacetic acid 
• 1206896-65-2 4-(2-chloro-phenyl)-2-methyl-buta-2,3-dienoic acid ethyl ester 
• 33155-60-1 t-butyl p-tolylacetate 

Downstream Products

• 92241-60-6 4,4'-[2-(p-tolyl)ethene-1,1-diyl]bis(methoxybenzene) 
• 57297-25-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone 
• 19715-81-2 N,N-dimethyl-2-(p-tolyl)acetamide 
• 15221-84-8 1-(4-chlorophenyl)-2-(p-tolyl)ethan-1-one 
• 51490-06-3 1,2-di-p-tolyl-ethanone 
• 60312-93-8 4'-methyl-4-phenyl-deoxybenzoin 
• 860571-16-0 4-methoxy-2,4'-dimethyl-deoxybenzoin 
• 118982-60-8 17-(4-methyl-phenethyl)-morphinan-3-ol 
• 21541-97-9 1-(4-methylphenyl)-2-hexanone 
• 95280-69-6 methyl 2-(2-(p-tolyl)acetoxy)benzoate 
• 35730-02-0 1-p-tolyl-3-phenylacetone 
• 64267-80-7 p-Tolyl-acetic acid N'-methyl-N'-phenyl-hydrazide 
• 81116-01-0 1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-2-p-tolyl-ethanone 
• 143659-25-0 1-Naphthylmethyl 4-methylphenylacetate 

Relevant articles and documents

Photoredox Catalyzed Sulfonylation of Multisubstituted Allenes with Ru(bpy)3Cl2 or Rhodamine B

A highly regio- and stereoselective sulfonylation of allenes was developed that provided direct access to α, β-substituted unsaturated sulfone. By means of visible-light photoredox catalysis, the free radicals produced by p-toluenesulfonic acid reacted with multisubstituted allenes to obtain Markovnikov-type vinyl sulfones with Ru(bpy)3Cl2 or Rhodamine B as photocatalyst. The yield of this reaction could reach up to 91%. A series of unsaturated sulfones would be used for further transformation to some valuable compounds.

Enhancement of the carbamate activation rate enabled syntheses of tetracyclic benzolactams: 8-oxoberbines and their 5- And 7-membered C-ring homologues

A route to the direct amidation of aromatic-ring-tetheredN-carbamoyl tetrahydroisoquinoline substrates was developed. This route enabled general access to 8-oxoberberines and their 5- and 7- membered C-ring homologues. It overcomes the undesired tandem side-reactions that result in the destruction of the isoquinoline backbone, which inevitably occurred under our previously reported superacidic carbamate activation method.

The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters

Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.