3581-30-4

Basic information

• Product Name: 4-morpholinedithiocarbamate
• Synonyms: 4-morpholinedithiocarbamate;4-Morpholinecarbodithioic acid;4-Morpholinedithiocarboxylic acid;Morpholine-4-carbodithioic acid;Morpholine-4-dithiocarboxylic acid;873-58-5 (Hydrochloride salt)
• CAS NO: 3581-30-4
• Molecular Formula: C₅H₉NOS₂
• Molecular Weight: 0
• Mol File: 3581-30-4.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 239°Cat760mmHg
• Flash Point: 98.4°C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: 4-morpholinedithiocarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-morpholinedithiocarbamate(3581-30-4)
• EPA Substance Registry System: 4-morpholinedithiocarbamate(3581-30-4)

Safety Data

• Hazardous Substances Data: 3581-30-4(Hazardous Substances Data)

Upstream product

• 110-91-8 morpholine 
• 50-00-0 formaldehyd 
• 5625-90-1 4-(morpholinomethyl)morpholine 
• 75-15-0 carbon disulfide 

Downstream Products

• 53043-09-7 N-(2,6-dimethyl-phenyl)-formimidic morpholine-4-carbothioic thioanhydride 
• 7022-01-7 benzoic morpholine-4-carbothioic thioanhydride 
• 58033-12-8 chloro-diphenyl-acetic morpholine-4-carbothioic thioanhydride 
• 127458-52-0 Morpholine-4-carbodithioic acid (E)-3-furan-2-yl-3-oxo-1-phenyl-propenyl ester 
• 127458-51-9 Morpholine-4-carbodithioic acid (E)-3-oxo-1-phenyl-3-thiophen-2-yl-propenyl ester 
• 127458-50-8 1,3-diphenyl-N,N-(3-oxapentamethylene)dithiocarbamoyl-1-propen-3-one 
• 110-91-8 morpholine 
• 729-46-4 4,4'-(dithiodicarbonothioyl)dimorpholine 
• 58033-10-6 (chloro-diphenyl-methyl)-(morpholine-4-carbothioyl)-disulfane 
• 58007-78-6 (morpholine-4-carbothioylsulfanyl)-diphenyl-acetic acid methyl ester 
• 58007-79-7 (morpholine-4-carbothioylsulfanyl)-diphenyl-acetic acid ethyl ester 
• 58007-80-0 (morpholine-4-carbothioylsulfanyl)-diphenyl-acetic acid propyl ester 
• 75-15-0 carbon disulfide 
• 1314227-93-4 morpholine-4-carbodithioic acid 3-acetylphenyl ester 

Relevant articles and documents

Biologically oriented organic sulfur chemistry. 9. Carbonyl and thiocarbamoyl disulfides as inhibitory agents for Histoplasma capsulatum.

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Synthesis, characterization, interactions with DNA and bovine serum albumin (BSA), and antibacterial activity of cyclometalated iridium(III) complexes containing dithiocarbamate derivatives

Three mononuclear cyclometalated iridium(III) complexes having dithiocarbamate ligands, [IrIII(2-C6H4py)2(L)] (where 2-C6H4py = 2-phenylpyridine; and L1H = 4-MePipzcdtH, L2

Dithiocarbamation of spiro-aziridine oxindoles: a facile access to C3-functionalised 3-thiooxindoles as apoptosis inducing agents

Herein, we report the first dithiocarbamation of spiro-aziridine oxindoles involving regiospecific ring-opening by usingin situgenerated nucleophilic dithiocarbamates as an instant source of sulfur. This approach afforded C3-functionalised-3-thiooxindoles in good to excellent yields with a wide substrate scope under catalyst-free and mild reaction conditions. These compounds were screened for their anticancer activity against a panel of human cancer cell lines, wherein compound3uexhibited significant cytotoxic activity against human lung cancer cells with an IC50value of 4.31 ± 1.88 μM. Phase contrast microscopy as well as different staining assays such as acridine orange/ethidium bromide (AO/EB), DAPI and DCFDA demonstrated the induction of apoptosis in A549 lung cancer cells after treatment with compound3u. In addition, the clonogenic assay and migration assay demonstrated the ability of compound3uto inhibit colony formation and cell migration, respectively, in A549 cells in a dose-dependent manner.

Synthesis of novel dithiocarbamates and xanthates using dialkyl azodicarboxylates: S–N bond formation

A one?pot three?component route for the synthesis of a novel category of dithiocarbamates or xanthates is developed by a reaction of in-situ generated dithiocarbamic acids or xanthates with dialkyl azodicarboxylates under mild and catalyst-free conditions. The reaction is characterized by a wide scope, high efficiency and straightforward isolation protocol. The synthetic utility of the dithiocarbamates and xanthates was demonstrated on the preparation of symmetrical and unsymmetrical thioureas, isothiocyanates, and thiocarbamates.