35842-45-6

Basic information

• Product Name: N-TIGLOYLGLYCINE
• Synonyms: N-TIGLOYLGLYCINE;Tigloylglycine;2-[[(E)-2-methylbut-2-enoyl]amino]acetic acid;Tiglylglycine;N-[(2E)-2-Methyl-1-oxo-2-buten-1-yl]glycine;N-Tiglylglycine;N-[(E)-2-Methyl-1-oxo-2-butenyl]glycine;N-Tigloylglycine-d2
• CAS NO: 35842-45-6
• Molecular Formula: C7H11NO3
• Molecular Weight: 157.17
• Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
• Mol File: 35842-45-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 86 °C
• Boiling Point: 394.9 °C at 760 mmHg
• Flash Point: 192.6 °C
• Appearance: /
• Density: 1.138 g/cm³
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: N-TIGLOYLGLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-TIGLOYLGLYCINE(35842-45-6)
• EPA Substance Registry System: N-TIGLOYLGLYCINE(35842-45-6)

Safety Data

• Hazardous Substances Data: 35842-45-6(Hazardous Substances Data)

Usage

Description

N-TIGLOYLGLYCINE, also known as an N-acylglycine, is a metabolite of Isoleucine with an amine hydrogen substituted by a 2-methylbut-2-enoyl (tiglyl) group. It is a white to off-white solid and has unique chemical properties that make it suitable for various applications across different industries.

Uses

Used in Pharmaceutical Industry:
N-TIGLOYLGLYCINE is used as a pharmaceutical compound for its potential therapeutic applications. Its unique structure allows it to interact with various biological targets, making it a promising candidate for the development of new drugs.
Used in Metabolic Research:
In the field of metabolic research, N-TIGLOYLGLYCINE is used as a metabolite of Isoleucine to study the metabolic pathways and functions of this essential amino acid. This can help researchers understand the role of Isoleucine in various physiological processes and its potential impact on health and disease.
Used in Chemical Synthesis:
N-TIGLOYLGLYCINE can be used as a starting material or intermediate in the synthesis of various chemical compounds, particularly those with potential applications in the pharmaceutical, agrochemical, or materials science industries.
Used in Analytical Chemistry:
As a unique compound with specific chemical properties, N-TIGLOYLGLYCINE can be used as a reference material or standard in analytical chemistry for the development and validation of analytical methods, such as chromatography or mass spectrometry.
Used in Nutritional Supplements:
Given its status as a metabolite of Isoleucine, N-TIGLOYLGLYCINE may be used as an ingredient in nutritional supplements designed to support protein synthesis, muscle growth, and overall health.

Upstream product

• 80-59-1 Tiglic acid 
• 56-40-6 glycine 
• 35660-94-7 (E)-2-methylbut-2-enoyl chloride 

Downstream Products

• 49659-62-3 4-(Z)-benzylidene-2-((E)-1-methyl-propenyl)-4H-oxazol-5-one 

Relevant articles and documents

N-Acylglycines: Gas chromatographic mass spectrometric identification and determination in urine by selected ion monitoring

Eleven biologically interesting N-acylglycines have been synthesized and the gas chromatographic and mass spectrometric properties of their trimethylsilyl derivatives studied. A sharp and reproducible gas chromatographic peak could be obtained for each n-acylglycine as the N,O-bis(trimethylsilyl)-N-acylglycine. By the use of these derivatives a sensitive and specific selected ion monitoring method for the determination of N-acylglycines in human urine has been developed.