35849-09-3

Basic information

• Product Name: 2-BROMOBENZALDEHYDE DIMETHYL ACETAL
• Synonyms: 2-BROMOBENZALDEHYDE DIMETHYL ACETAL;1-broMo-2-(diMethoxyMethyl)benzene
• CAS NO: 35849-09-3
• Molecular Formula: C₉H₁₁BrO₂
• Molecular Weight: 231.09
• Product Categories: Adehydes, Acetals & Ketones;Bromine Compounds
• Mol File: 35849-09-3.mol
• Article Data: 45

Chemical Properties

• Boiling Point: 102-103 °C(Press: 6 Torr)
• Appearance: /
• Density: 1.372±0.06 g/cm3(Predicted)
• Refractive Index: 1.54
• CAS DataBase Reference: 2-BROMOBENZALDEHYDE DIMETHYL ACETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMOBENZALDEHYDE DIMETHYL ACETAL(35849-09-3)
• EPA Substance Registry System: 2-BROMOBENZALDEHYDE DIMETHYL ACETAL(35849-09-3)

Safety Data

• Hazardous Substances Data: 35849-09-3(Hazardous Substances Data)

Usage

General Description

2-Bromobenzaldehyde dimethyl acetal is a chemical compound that falls under the category of aromatic halogen compounds. It is also known as dimethyl 2-formylphenyl bromide. The formula for this compound is C9H9BrO2. This substance is used mainly in the field of chemistry as a reagent or intermediate compound in the synthesis of other compounds, notably in pharmaceuticals and biochemical research. Due to its potential hazards, handling and storage have to be done with the necessary precautions due to its reactivity and the possibility of it producing harmful and hazardous effects.

Upstream product

• 67-56-1 methanol 
• 35849-08-2 1-bromo-2-(dibromomethyl)benzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 149-73-5 trimethyl orthoformate 
• 95-46-5 2-methylphenyl bromide 
• 76-26-6 camphor-10-sulfonic acid 
• 2039-88-5 2-bromostyrene 

Downstream Products

• 1005759-26-1 meso-1,2-bis-(2'-bromophenyl)-1,2-dimethoxyethane 
• 130674-21-4 d,l-1,2-bis-(2'-bromophenyl)-1,2-dimethoxyethane 
• 140484-59-9 Lithium; 2-dimethoxymethyl-benzeneselenolate 
• 132233-84-2 2-(dimethoxymethyl)benzaldehyde 
• 133625-50-0 (1'RS)-1-<1'-(2''-Bromophenyl)-1'-methoxymethyl>uracil 
• 65654-63-9 Bis-(2-dimethoxymethyl-phenyl)-phenyl-phosphane 
• 176017-93-9 (S)-2-<4-Hydroxy-2-<(2-methoxyethoxy)methoxy>butanoyl>benzaldehyde dimethyl acetal 
• 187325-01-5 1-(2-Dimethoxymethyl-phenyl)-4-hydroxy-2-(2-methoxy-ethoxymethoxy)-butan-1-one 
• 176017-92-8 (-)-<(2S,4S)-2-(2-Bromophenyl)-1,3-dioxan-4-yl>methanol 
• 114574-44-6 2-(3,4-dimethoxy-α-hydroxybenzyl)benzaldehyde dimethylacetal 
• 1026882-08-5 (2-bromo-pyridin-4-yl)-(2-dimethoxymethyl-phenyl)-methanol 
• 233662-89-0 (2-dimethoxymethyl-phenyl)-(2-phenyl-phenyl)-methanol 
• 251982-51-1 1,2-Bis{di[2'-(dimethoxymethyl)phenyl]phosphanyl}benzene 
• 251982-49-7 (1S,2S)-1,2-Bis{di[2'-(dimethoxymethyl)phenyl]phosphanyl}cyclopentane 

Relevant articles and documents

Sustainable Passerini-tetrazole three component reaction (PT-3CR): selective synthesis of oxaborol-tetrazoles

A sustainable catalyst- and solvent-free Passerini-tetrazole three component reaction (PT-3CR) has been developed for the selective synthesis of benzoxaborol-tetrazoles for the first time. The synthetic potential of oxaboroles was demonstrated towards various functionalized tetrazoles, which are otherwise difficult to achieve through conventional PT-3CR from aromatic aldehydes/ketones. The reaction features high practicality, broad substrate scope and excellent yields (80-98%). Preliminary results of the asymmetric PT-3CR are also shown for the synthesis of chiral benzoxaboroles.

Palladium-Catalyzed Intramolecular Mizoroki-Heck-Type Reaction of Diarylmethyl Carbonates

A palladium-catalyzed intramolecular Mizoroki-Heck-type reaction of diarylmethyl tert-butyl carbonates has been developed. The reaction proceeds under external base-free, neutral conditions to form the corresponding methyleneindanes in good yields only with liberation of CO2 and tBuOH. The resulting exo-methylene moiety is reactive and thus a good synthetic handle for further manipulations. Additionally, the asymmetric synthesis is also possible through a Pd/chiral Mandyphos ligand-mediated kinetic resolution. To the best of our knowledge, this is the first successful example of catalytic enantioselective Mizoroki-Heck-type reaction of secondary benzyl electrophiles. (Figure presented.).

HETEROCYCLIC SPIRO-COMPOUNDS AS AM2 RECEPTOR INHIBITORS

Disclosed are compounds of the formula (I) and pharmaceutically acceptable salts thereof: wherein R1, R2, R4, R5, R6, R7, R8, R9, R10,Z, X1, X2, X3, L2, HET, n and q are as defined herein. The compounds are inhibitors of adrenomedullin receptor subtype 2 (AM2). Also disclosed are the compounds for use in the treatment of diseases modulated AM2, including proliferative diseases such as cancer; pharmaceutical compositions comprising the compounds; methods for preparing the compounds; and intermediates useful in the preparation of the compounds.