35978-39-3 Usage
Description
7-Phenyl-9-thia-2,4-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one is a complex organic compound with a unique molecular structure that features a phenyl group, a thiophene ring, and a diazabicyclo framework. 7-phenyl-9-thia-2,4-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one has potential applications in various fields due to its chemical properties and reactivity.
Uses
Used in Pharmaceutical Industry:
7-Phenyl-9-thia-2,4-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one is used as a reagent for the preparation of c-Met kinase inhibitors bearing thieno-pyrimidine or furo-pyrimidine scaffolds. These inhibitors have potential antitumor properties, making them valuable in the development of new cancer treatments.
Used in Chemical Research:
Due to its unique structure and reactivity, 7-phenyl-9-thia-2,4-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one can be utilized in chemical research to explore new reactions and synthesize novel compounds with potential applications in various industries, such as pharmaceuticals, materials science, and agrochemicals.
Used in Drug Design:
7-phenyl-9-thia-2,4-diazabicyclo[4.3.0]nona-2,7,10-trien-5-one's structural features make it a promising candidate for drug design, particularly in the development of targeted therapies for cancer and other diseases. Its ability to form specific interactions with biological targets can be exploited to create more effective and selective drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 35978-39-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,5,9,7 and 8 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 35978-39:
(7*3)+(6*5)+(5*9)+(4*7)+(3*8)+(2*3)+(1*9)=163
163 % 10 = 3
So 35978-39-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H8N2OS/c15-11-10-9(8-4-2-1-3-5-8)6-16-12(10)14-7-13-11/h1-7H,(H,13,14,15)
35978-39-3Relevant articles and documents
Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction
Actis, Marcelo L.,Ambaye, Nigus D.,Evison, Benjamin J.,Shao, Youming,Vanarotti, Murugendra,Inoue, Akira,McDonald, Ezelle T.,Kikuchi, Sotaro,Heath, Richard,Hara, Kodai,Hashimoto, Hiroshi,Fujii, Naoaki
, p. 4339 - 4346 (2016)
DNA interstrand crosslink (ICL) repair (ICLR) has been implicated in the resistance of cancer cells to ICL-inducing chemotherapeutic agents. Despite the clinical significance of ICL-inducing chemotherapy, few studies have focused on developing small-molec
ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE 1 (ENPP1) MODULATORS AND USES THEREOF
-
, (2021/07/02)
Provided herein are small molecule modulators of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
Identification of 4-methoxythieno[2,3-d]pyrimidines as FGFR1 inhibitors
Balanda, A. O.,Bdzhola, V. G.,Kotey, I. M.,Pletnova, L. V.,Protopopov, M. V.,Prykhod’ko, A. O.,Starosyla, S. A.,Yarmoluk, S. M.
, p. 152 - 162 (2020/06/02)
Aim. To identify novel FGFR1 inhibitors using virtual screening approach. Methods. We used methods of organic synthesis, molecular docking via the Autodock 4.2.6 program package and in vitro biochemical tests with γ-32P. Results. In vitro experiments showed that 9 of 23 tested compounds possess inhibitory activity against FGFR1 with IC50 values in the range from 0.9 to 5.6 μM. Conclusions. Nine FGFR1 inhibitors were developed. The mode of compounds binding with the ATP-acceptor site was determined using molecular docking methods and the dependence of the compounds’ activity on the substituents R1, R4 and R5 was evaluated.