3598-60-5

Basic information

• Product Name: 4-(Phthalimidyl)butanal
• Synonyms: 4-(Phthalimidyl)butanal;4-Phthalimidylbutyraldehyde;N-(3-Formylpropyl)phthalimide;4-[1,3-bis(oxidanylidene)isoindol-2-yl]butanal;4-phthalimidobutyraldehyde;4-(1,3-Diketoisoindolin-2-Yl)Butyraldehyde;4-(1,3-Dioxo-2-Isoindolinyl)Butanal;4-(1,3-Dioxoisoindol-2-Yl)Butanal 4-(1,3-Dioxoisoindolin-2-Yl)Butanal
• CAS NO: 3598-60-5
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.23
• Mol File: 3598-60-5.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 373.9°Cat760mmHg
• Flash Point: 173.7°C
• Appearance: /
• Density: 1.274g/cm³
• Vapor Pressure: 8.67E-06mmHg at 25°C
• Refractive Index: 1.576
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• CAS DataBase Reference: 4-(Phthalimidyl)butanal(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Phthalimidyl)butanal(3598-60-5)
• EPA Substance Registry System: 4-(Phthalimidyl)butanal(3598-60-5)

Safety Data

• Hazardous Substances Data: 3598-60-5(Hazardous Substances Data)

Usage

Description

4-(Phthalimidyl)butanal is a chemical compound with the molecular formula C12H11NO2. It is a derivative of phthalimide and has a butanal group attached to it. This white to off-white solid is sparingly soluble in water and is primarily used in research and development processes. As a key intermediate, it plays a significant role in the production of pharmaceuticals, dyes, and agricultural chemicals.

Uses

Used in Pharmaceutical Industry:
4-(Phthalimidyl)butanal is used as a key intermediate for the synthesis of various pharmaceuticals. Its unique structure allows it to be a building block in the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Dye Industry:
In the dye industry, 4-(Phthalimidyl)butanal is utilized as a crucial intermediate in the production of different types of dyes. Its chemical properties make it suitable for creating a wide range of colorants used in various applications.
Used in Agricultural Chemicals Industry:
4-(Phthalimidyl)butanal is also employed as an intermediate in the synthesis of agricultural chemicals. Its role in this industry is vital for the development of effective products that contribute to enhanced crop protection and yield.
It is important to handle 4-(Phthalimidyl)butanal with care due to its potential health hazards. It should be used in a well-ventilated area and with the appropriate personal protective equipment to ensure safety during research, development, and production processes.

InChI:InChI=1/C12H11NO3/c14-8-4-3-7-13-11(15)9-5-1-2-6-10(9)12(13)16/h1-2,5-6,8H,3-4,7H2

Upstream product

• 10314-06-4 4-phthalimidobutyryl chloride 
• 85-44-9 phthalic anhydride 
• 83179-86-6 2-(buta-2,3-dien-1-yl)-2,3-dihydro-1H-isoindole-1,3-dione 
• 100-51-6 benzyl alcohol 

Downstream Products

• 149194-43-4 diphenyl benzyloxycarbonylamino-(3-phthalimidopropyl)methanephosphonate 
• 146548-65-4 [1-Amino-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphonic acid diphenyl ester 
• 94830-02-1 2-{4-[(4-Chloro-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94830-01-0 2-{4-[(2-Methoxy-4-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 94830-00-9 2-{4-[(4-Methoxy-2-nitro-phenyl)-hydrazono]-butyl}-isoindole-1,3-dione 
• 133787-02-7 α-N-benzoyl-δ-N-phthaloylornithine 
• 74510-03-5 1,3-Diphenyl-7-phthalimido-1,4-heptandion 
• 95711-01-6 [1-(Benzhydryl-amino)-4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-butyl]-phosphinic acid 
• 74510-02-4 1-Phenyl-7-phthalimido-1,4-heptandion 
• 20820-73-9 1,4-diaminobutylphosphonic acid 
• 19991-87-8 Methyl 6-phthalimidohex-2-enoate 
• 176982-87-9 2-(4-Benzyloxy-3,5-dimethoxy-phenyl)-6-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-hydroxy-2-morpholin-4-yl-hexanenitrile 
• 1026634-99-0 4-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-1,4-dihydro-pyridine-3-carboxylic acid ethyl ester 
• 901773-73-7 [4-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-1-formylamino-butyl]-phosphonic acid diphenyl ester 

Relevant articles and documents

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Synthesis of Vinyl Isocyanides and Development of a Convertible Isonitrile

The reaction of isocyanomethylenetriphenylphosphorane, generated in situ from the corresponding phosphonium salt, with a diverse set of aldehydes afforded vinyl isocyanides in good to high yields. Excellent E-selectivity was observed for aliphatic aldehydes and 2,6-disubstituted aromatic aldehydes, whereas Z-olefins were formed predominantly with ortho-substituted aryl aldehydes. (Z)-1-Bromo-2-(2-isocyanovinyl)benzene (5l) was found to be a truly universal isonitrile since, after Ugi reaction, the resulting secondary amide unit (RNHCO-) is convertible under both acidic and basic conditions. The application of 5l in the synthesis of polyheterocycles is also illustrated.