3608-81-9

Basic information

• Product Name: quinoline-2-carbaldehyde thiosemicarbazone
• Synonyms: (2E)-2-(Quinolin-2-ylmethylene)hydrazinecarbothioamide; Hydrazinecarbothioamide, 2-(2-quinolinylmethylene)-, (2E)-
• CAS NO: 3608-81-9
• Molecular Formula: C₁₁H₁₀N₄S
• Molecular Weight: 230.2889
• Mol File: 3608-81-9.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 432.6°C at 760 mmHg
• Flash Point: 215.4°C
• Density: 1.33g/cm³
• Vapor Pressure: 1.1E-07mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: quinoline-2-carbaldehyde thiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: quinoline-2-carbaldehyde thiosemicarbazone(3608-81-9)
• EPA Substance Registry System: quinoline-2-carbaldehyde thiosemicarbazone(3608-81-9)

Safety Data

• Hazardous Substances Data: 3608-81-9(Hazardous Substances Data)

Usage

General Description

Quinoline-2-carbaldehyde thiosemicarbazone, also known as TCQ, is a chemical compound with potential anti-tumor and anti-malarial properties. It has been studied for its ability to inhibit the growth of cancer cells and has shown promise as a potential chemotherapeutic agent. TCQ has also demonstrated activity against the parasite that causes malaria, making it a potential candidate for the development of new anti-malarial drugs. Additionally, TCQ has been investigated for its ability to inhibit the activity of certain enzymes involved in the progression of neurological diseases, making it a promising candidate for the treatment of such conditions. Overall, TCQ shows great potential for the development of new therapies for cancer, malaria, and neurological disorders.

Upstream product

• 5470-96-2 quinoline 2-carbaldehyde 
• 79-19-6 thiosemicarbazide 

Relevant articles and documents

In vitro evaluation of the activity of thiosemicarbazone derivatives against mycotoxigenic fungi affecting cereals

With a steadily increasing world population, a more efficient system of food production is of paramount importance. One of the major causes of food spoilage is the presence of fungal pathogens and the production and accumulation of mycotoxins. In the pres

A new nickel(II) complex with the thiosemicarbazone of quinoline-2- carboxaldehyde: Structure, DNA-binding, cleavage, and cytotoxic activities

[Ni(QTS)2]ClCH3OH, where QST=quinoline-2- carboxaldehyde thiosemicarbazone, has been synthesized and characterized. The complex crystallized in a monoclinic system with space group P2(1)/n. Nickel(II) is situated in a distorted octahedral geometry with two tridentate ligands and one ligand is mono-deprotonated to coordinate to nickel(II). Interaction of the nickel(II) complex with calf thymus DNA was investigated by electronic absorption, CD, and fluorescence spectra. The results suggest that nickel(II) complex binds to DNA through a groove binding mode. The nickel(II) complex exhibited efficient DNA cleavage at micromolar concentration in the presence of ascorbate with hydroxyl radicals as the active species. Invitro cytotoxicity assay showed that the nickel(II) complex was more potent against MCF-7 cell line but less active against A-549 cell line than cisplatin at the concentrations tested.

Dual-mode chemosensor and heavy metal detection method using thereof

[Schiff base] The present invention relates to compositions and the like for detecting heavy metal ions comprising novel zeroes. Since the chemical sensor using Schiff base can determine whether heavy metal is contained in the specimen, it is convenient t