36116-18-4

Basic information

• Product Name: Cyclopropy(4-hydroxyphenyl)Methanone
• Synonyms: Cyclopropy(4-hydroxyphenyl)Methanone;4-hydroxyphenylcyclopropyl ketone;Methanone, cyclopropyl(4-hydroxyphenyl)-;4-(Cyclopropylcarbonyl)phenol;Cyclopropyl p-hydroxyphenyl ketone
• CAS NO: 36116-18-4
• Molecular Formula: C₁₀H₁₀O₂
• Molecular Weight: 162.1852
• Mol File: 36116-18-4.mol
• Article Data: 21

Chemical Properties

• Melting Point: 105-107 °C
• Boiling Point: 335.5±15.0 °C(Predicted)
• Appearance: /
• Density: 1.260±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.09±0.15(Predicted)
• CAS DataBase Reference: Cyclopropy(4-hydroxyphenyl)Methanone(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropy(4-hydroxyphenyl)Methanone(36116-18-4)
• EPA Substance Registry System: Cyclopropy(4-hydroxyphenyl)Methanone(36116-18-4)

Safety Data

• Hazardous Substances Data: 36116-18-4(Hazardous Substances Data)

Usage

General Description

Cyclopropy(4-hydroxyphenyl)methanone, also known as 2-Phenylcyclopropanone, is a chemical compound consisting of a cyclopropyl ring attached to a phenyl group and a ketone functional group. It is commonly used in the synthesis of pharmaceutical drugs and organic compounds due to its reactivity and versatility as a building block in organic chemistry. The compound exhibits potential for biological activity and has been studied for its anti-inflammatory and antioxidant properties. Additionally, it is utilized as an intermediate in the production of various pharmaceuticals, agrochemicals, and fine chemicals. However, further research is required to fully understand its potential applications and effects.

Upstream product

• 7150-55-2 γ-chloro-4-hydroxybutyrophenone 
• 3874-54-2 4-(4-fluorophenyl)-4-oxo-n-butyl chloride 
• 7152-03-6 p-methoxyphenyl cyclopropyl ketone 
• 873-75-6 4-bromobenzenemethanol 
• 1759-53-1 cyclopropanecarboxylic acid 
• 108-95-2 phenol 
• 113425-33-5 4-hydroxy-1-(4-hydroxyphenyl)-butan-1-one 
• 100-66-3 methoxybenzene 
• 4023-34-1 cyclopropanecarboxylic acid chloride 
• 6746-94-7 Cyclopropylacetylene 
• 106-51-4 p-benzoquinone 

Downstream Products

• 61025-34-1 1-(4-hydroxy-phenyl)-4-morpholin-4-yl-butan-1-one 
• 36116-10-6 {4-[3-(4-Cyclopropanecarbonyl-phenoxy)-2-hydroxy-propoxy]-phenyl}-cyclopropyl-methanone 
• 315674-93-2 cyclopropyl-{4-[3-(1-trityl-1H-imidazol-4-yl)-propoxy]-phenyl}-methanone 
• 360553-46-4 (4-(3-chloropropoxy)phenyl)(cyclopropyl)methanone 

Relevant articles and documents

In situ cyclopropanation: A rapid one-pot method for the synthesis of resin bound cyclopropyl phenyl methanones as combinatorial scaffolds

An efficient, high yielding one-pot synthesis of 4-substituted cyclopropyl phenyl methanones bound to RAM and WANG resins has been developed. The resin bound cyclopropyl phenyl methanone served as a combinatorial scaffold for the generation of structurally diverse alicyclic compounds.

Visible Light-Mediated [2 + 2] Cycloaddition Reactions of 1,4-Quinones and Terminal Alkynes

A single-step synthesis of 4-hydroxy-functionalized bi-aryl and aryl/alkyl ketones via oxidative coupling of terminal alkynes with benzoquinones is reported. Furthermore, with naphthoquinones, owing to the cross-resonance of carbonyl with the aromatic ring, alkene-alkyne cycloaddition is more favored to give four-membered carbocyclic adducts, thereby precluding the requirement of preactivated alkynes.

AZETIDINE COMPOUNDS AS GRP119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY, DYSLIPIDEMIA AND RELATED DISORDERS

The present disclosure relates to azetidine compounds. The azetidine compounds are GPR119 modulators and useful for the prevention and/or treatment of diabetes, obesity, dyslipidemia and related disorders. The present disclosure furthermore relates to the use of azetidine compounds as active ingredients in pharmaceuticals, and pharmaceutical compositions comprising them.