361379-88-6

Basic information

• Product Name: (2R,3aR,6aR)-1-[5-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester
• Synonyms: (2R,3aR,6aR)-1-[5-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester
• CAS NO: 361379-88-6
• Molecular Weight: 528.992
• Mol File: 361379-88-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3aR,6aR)-1-[5-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3aR,6aR)-1-[5-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester(361379-88-6)
• EPA Substance Registry System: (2R,3aR,6aR)-1-[5-Chloro-2-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-benzoyl]-octahydro-cyclopenta[b]pyrrole-2-carboxylic acid benzyl ester(361379-88-6)

Safety Data

• Hazardous Substances Data: 361379-88-6(Hazardous Substances Data)

Upstream product

• 129101-19-5 (all-R)-2-Azabicyclo[3.3.0]octan-3-oic acid benzyl ester p-toluenesulfonate 

Relevant articles and documents

Stereoselective synthesis of 1,4-benzodiazepines via photoinduced decarboxylation of N-phthaloylanthranilic acid amides

Photochemical decarboxylation of amides derived from N-phthaloylanthranilic acid coupled to a series of α-amino acids under basic conditions resulted in 1,4-benzodiazepines (from sarcosine, alanine, valine, leucine, phenylalanine, aspartic and glutamic acid) and several annulated (from 2-azetidine and pipecolinic acid, proline and 2-azabicyclo[3.3.0]undecanoic acid) 1,4-benzodiazepines 1c-12c in good yields (except for 6c and 7c from acidic amino acids and 9c) and excellent diastereoselectivities. Also quaternary α-amino acids could be applied as demonstrated for the α-amino isobuyrate derivative 8b. Optically active substrates 9b, 10b, 10e, 12b, and 12e were converted into non-racemic products with a high degree of chirality memory with (inversion of configuration at the stereogenic center) and ee-values of >79%. The corresponding 4-chlorinated products 1e-12e were obtained in comparable yields from the 4-chloroanthranilic acid-derived substrates.