361382-81-2 Usage
General Description
1H-Imidazo[4,5-b]pyrazin-2-amine is a chemical compound with the molecular formula C6H6N6. It is a heterocyclic compound that contains an imidazole ring fused to a pyrazine ring, with an amine functional group attached to the carbon 2 position. 1H-Imidazo[4,5-b]pyrazin-2-amine is used in medicinal chemistry as a building block for the synthesis of various pharmaceutical compounds, particularly those targeting the central nervous system. It has also been studied for its potential as an anti-cancer agent, with research indicating its ability to inhibit the growth of tumor cells. Additionally, 1H-Imidazo[4,5-b]pyrazin-2-amine has been investigated for its anti-inflammatory and anti-viral properties, making it a versatile and important chemical in the field of drug discovery and development.
Check Digit Verification of cas no
The CAS Registry Mumber 361382-81-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,6,1,3,8 and 2 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 361382-81:
(8*3)+(7*6)+(6*1)+(5*3)+(4*8)+(3*2)+(2*8)+(1*1)=142
142 % 10 = 2
So 361382-81-2 is a valid CAS Registry Number.
InChI:InChI=1/C5H5N5/c6-5-9-3-4(10-5)8-2-1-7-3/h1-2H,(H3,6,7,8,9,10)
361382-81-2Relevant articles and documents
Dienophilicity of imidazole in inverse electron demand Diels-Alder reactions: Cycloadditions with 1,2,4,5-tetrazines and the structure of zarzissine
Wan, Zhao-Kui,Woo, Grace H.C.,Snyder, John K.
, p. 5497 - 5507 (2007/10/03)
The inverse electron demand cycloadditions of 2-substituted imidazoles with dimethyl 1,2,4,5-tetrazine-3,6-dicarboxylate produced imidazo[4,5-d]pyridazines in good yields. This chemistry was applied to the synthesis of 2-amino-1H-imidazo[4,5-d]pyridazine (1), the structure reported for zarzissine, a cytotoxic marine alkaloid. Differences in the 1H- and 13C NMR spectra of 1 with those reported for zarzissine necessitated a structural revision, and zarzissine was then considered to be the corresponding 2-amino-1H-imidazo[4,5-b]pyrazine (2), which was subsequently synthesized from the parent heterocycle.
