36148-89-7 Usage
Description
Amphotericin B is a polyene antibiotic that is commonly used in the treatment of systemic fungal infections. It is a cholesterol binding compound that exhibits inhibitory activity against human immunodeficiency virus type 1 (HIV-1). Amphotericin B Methyl Ester is a methyl ester derivative of Amphotericin B, which has been developed to improve its pharmacological properties.
Uses
Used in Pharmaceutical Industry:
Amphotericin B is used as an antifungal agent for the treatment of systemic fungal infections, particularly those caused by Candida and Aspergillus species. It is particularly effective against infections that are resistant to other antifungal drugs.
Amphotericin B is also used as an antiviral agent for the treatment of human immunodeficiency virus type 1 (HIV-1) infection. It inhibits the replication of the virus by binding to cholesterol in the viral envelope, thereby disrupting its structure and function.
In addition to its therapeutic uses, Amphotericin B Methyl Ester has been studied for its potential as a cholesterol-lowering agent. By binding to cholesterol, it may help to reduce the levels of this lipid in the blood, which could have potential benefits for cardiovascular health.
Overall, Amphotericin B and its derivatives have a range of applications in the pharmaceutical industry, particularly in the treatment of fungal and viral infections, as well as in the development of novel drug delivery systems for improved efficacy and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 36148-89-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,1,4 and 8 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 36148-89:
(7*3)+(6*6)+(5*1)+(4*4)+(3*8)+(2*8)+(1*9)=127
127 % 10 = 7
So 36148-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C48H75NO17/c1-28-18-16-14-12-10-8-6-7-9-11-13-15-17-19-35(65-47-45(59)42(49)44(58)31(4)64-47)25-39-41(46(60)62-5)38(55)27-48(61,66-39)26-34(52)22-32(50)20-21-36(53)37(54)23-33(51)24-40(56)63-30(3)29(2)43(28)57/h6-19,28-39,41-45,47,50-55,57-59,61H,20-27,49H2,1-5H3/b7-6-,10-8-,11-9-,14-12-,15-13-,18-16-,19-17-/t28-,29+,30-,31+,32-,33+,34-,35-,36-,37-,38-,39-,41+,42-,43+,44+,45-,47-,48+/m0/s1
36148-89-7Relevant articles and documents
Synthesis and biological evaluation of non-polyene analogs of amphotericin B
Rogers, Bruce N.,Selsted, Michael E.,Rychnovsky, Scott D.
, p. 3177 - 3182 (1997)
Synthesis of the first analog of a polyene macrolide antibiotic containing a rigid, non-polyene backbone has been accomplished. The sterol recognition surface of amphotericin B has been modified in an effort to better understand the role of the polyene backbone. Its antifungal activity is reduced significantly compared with amphotericin B.