36155-78-9

Basic information

• Product Name: 4-Bromo-2-propionylthiophene
• Synonyms: 1-(4-Bromothiophen-2-yl)propan-1-one
• CAS NO: 36155-78-9
• Molecular Formula: C7H7BrOS
• Molecular Weight: 0
• Mol File: 36155-78-9.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 294.9°C at 760 mmHg
• Flash Point: 132.2°C
• Appearance: /
• Density: 1.53g/cm³
• Vapor Pressure: 0.00158mmHg at 25°C
• Refractive Index: 1.57
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-Bromo-2-propionylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-2-propionylthiophene(36155-78-9)
• EPA Substance Registry System: 4-Bromo-2-propionylthiophene(36155-78-9)

Safety Data

• Hazardous Substances Data: 36155-78-9(Hazardous Substances Data)

Usage

Description

4-Bromo-2-propionylthiophene is a chemical compound with the molecular formula C8H7BrS. It is a thiophene derivative that contains a bromine atom and a propionyl group. 4-Bromo-2-propionylthiophene is known for its unique properties and reactivity, making it a valuable component in various chemical processes.

Uses

Used in Pharmaceutical Synthesis:
4-Bromo-2-propionylthiophene is used as a building block for the synthesis of pharmaceuticals due to its unique structure and reactivity. It contributes to the development of new drugs and agrochemicals, enhancing the range of available chemical entities for medical and agricultural applications.
Used in Organic Material Synthesis:
In the field of organic materials, 4-Bromo-2-propionylthiophene is utilized as a key component in the preparation of heterocyclic compounds. Its presence in these compounds can influence their properties, making them suitable for a variety of applications.
Used in Materials Science:
4-Bromo-2-propionylthiophene is also studied for its potential applications in materials science. It has been considered for use in the production of organic electronic devices and photovoltaic cells, where its unique characteristics can contribute to improved performance and efficiency.
Safety Note:
It is important to handle 4-Bromo-2-propionylthiophene with caution, as it may pose health and safety risks if not managed properly. Adequate safety measures should be taken to minimize any potential hazards associated with its use.

InChI:InChI=1/C7H7BrOS/c1-2-6(9)7-3-5(8)4-10-7/h3-4H,2H2,1H3

Upstream product

• 13679-75-9 1-thiophen-2-yl-propan-1-one 
• 341006-27-7 1-(4-bromo-2-thiophenyl)-1-propanol 

Downstream Products

• 36155-79-0 4-bromo-2-propyl thiophene 
• 178201-92-8 (2R)-4-(3,4-Dimethoxyphenyl)-1-(2-propyl-thien-4-yl)-2-(trifluoroacetyl)-amino-1-butanone 
• 918487-51-1 C₁₇H₁₅BrO₄S 

Relevant articles and documents

New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2′ region

The proteolytic enzyme β-secretase (BACE1) plays a central role in the synthesis of the pathogenic β-amyloid in Alzheimer's disease. SAR studies of the S2′ region of the BACE1 ligand binding pocket with pyrazolyl and thienyl P2′ side chains are reported. These analogs exhibit low nanomolar potency for BACE1, and demonstrate >50- to 100-fold selectivity for the structurally related aspartyl proteases BACE2 and cathepsin D. Small groups attached at the nitrogen of the P2′ pyrazolyl moiety, together with the P3 pyrimidine nucleus projecting into the S3 region of the binding pocket, are critical components to ligand's potency and selectivity. P2′ thiophene side chain analogs are highly potent BACE1 inhibitors with excellent selectivity against cathepsin D, but only modest selectivity against BACE2. The cell-based activity of these new analogs tracked well with their increased molecular binding with EC50 values of 0.07-0.2 μM in the ELISA assay for the most potent analogs.

Vitamin D analogues

The present invention relates to novel triaromatic compounds having the general formula (I): as well as to a method for preparing them and to their use in pharmaceutical compositions intended for use in human or veterinary medicine (in dermatology, in car

An efficient enantioselective synthesis of the D1 agonist (5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A-86929)

(5aR,11bS)-4,5,5a,6,7,11b-Hexahydro-2-propyl-3-thia-5-azacyclopenta[c] phenanthrene-9,10-diol (A86929, 1), a potent selective dopamine D1 agonist, was synthesized enantioselectively from D-aspartic acid. Key features of the 10-step synthesis are the follo