3616-08-8

Basic information

• Product Name: CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE
• Synonyms: CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE;CYTIDINE-3',5'-CYCLIC MONOPHOSPHATE;CYTIDINE-3':5'-CYCLIC MONOPHOSPHORIC ACID;3',5'-CCMP;3:5-CCMP;cycliccmp;cytidine 3':5'-cyclic monophosphate*free acid;CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE FRE&
• CAS NO: 3616-08-8
• Molecular Formula: C₉H₁₂N₃O₇P
• Molecular Weight: 305.18
• Mol File: 3616-08-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 580.6 °C at 760 mmHg
• Flash Point: 305 °C
• Appearance: White crystalline powder
• Density: 2.28 g/cm³
• Storage Temp.: Store at 0°C
• PKA: 0.97±0.60(Predicted)
• CAS DataBase Reference: CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE(CAS DataBase Reference)
• NIST Chemistry Reference: CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE(3616-08-8)
• EPA Substance Registry System: CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE(3616-08-8)

Safety Data

• Hazardous Substances Data: 3616-08-8(Hazardous Substances Data)

Usage

Description

CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE, also known as cCMP, is a 3',5'-cyclic pyrimidine nucleotide that features cytosine as its nucleobase. It is a white crystalline powder and is a derivative of cytidine, a nucleoside that plays a crucial role in various biological processes.

Uses

Used in Pharmaceutical Industry:
CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE is used as a research compound for studying its potential role in the regulation of cellular processes and its interaction with other biomolecules. It may have implications in the development of new therapeutic agents targeting specific cellular pathways.
Used in Biochemical Research:
In the field of biochemical research, CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE is utilized as a tool to investigate the mechanisms of nucleotide signaling and their influence on cellular functions. This can contribute to a better understanding of various biological phenomena and the discovery of novel bioactive molecules.
Used in Diagnostic Applications:
CYTIDINE 3':5'-CYCLIC MONOPHOSPHATE may also be employed in diagnostic applications, where it can serve as a biomarker or a component in assays designed to detect and monitor specific biological conditions or diseases.

Upstream product

• 63-37-6 cytidine monophosphate 
• 65-47-4 cytidine triphosphate 

Downstream Products

• 71-30-7 Cytosine 
• 84-52-6 cytidine 3'-monophosphate 
• 63-37-6 cytidine monophosphate 
• 85-94-9 cytidine-2'-monophosphate 
• 87072-97-7 N⁴,O^2'-di-isobutyrylcytidine cyclic 3',5'-phosphoranilidate (R(P)) 
• 87063-78-3 N⁴,O^2'-di-isobutyrylcytidine cyclic 3',5'-phosphoranilidate (S(P)) 

Relevant articles and documents

Cytidylyl and uridylyl cyclase activity of bacillus anthracis edema factor and bordetella pertussis CyaA

Cyclic adenosine 3′,5′-monophosphate (cAMP) and cyclic guanosine 3′,5′-monophosphate (cGMP) are second messengers for numerous mammalian cell functions. The natural occurrence and synthesis of a third cyclic nucleotide (cNMP), cyclic cytidine 3′,5′-monophosphate (cCMP), is a matter of controversy, and almost nothing is known about cyclic uridine 3′,5′-monophosphate (cUMP). Bacillus anthracis and Bordetella pertussis secrete the adenylyl cyclase (AC) toxins edema factor (EF) and CyaA, respectively, weakening immune responses and facilitating bacterial proliferation. A cell-permeable cCMP analogue inhibits human neutrophil superoxide production. Here, we report that EF and CyaA also possess cytidylyl cyclase (CC) and uridylyl cyclase (UC) activity. CC and UC activity was determined by a radiometric assay, using [α-32P]CTP and [α-32P]UTP as substrates, respectively, and by a high-performance liquid chromatography method. The identity of cNMPs was confirmed by mass spectrometry. On the basis of available crystal structures, we developed a model illustrating conversion of CTP to cCMP by bacterial toxins. In conclusion, we have shown both EF and CyaA have a rather broad substrate specificity and exhibit cytidylyl and uridylyl cyclase activity. Both cCMP and cUMP may contribute to toxin actions.

Novel preparation of cytidine 5' phosphate and cytidine 3',5' cyclic phosphate

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