362-56-1Relevant articles and documents
Synthesis method of 1, 4-dimethoxy tetrafluorobenzene
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Paragraph 0010; 0031; 0033-0034; 0035; 0037-0038; 0040-0041, (2021/07/11)
The invention discloses a synthesis method of 1, 4-dimethoxy tetrafluorobenzene, the synthesis method comprises the following steps: (1) reacting N, N-dimethyl pentafluoroaniline with sodium methoxide to obtain an intermediate I; (2) mixing the intermediate I with a first organic solvent, and then reacting with methyl trifluoromethanesulfonate to obtain an intermediate II; and (3) mixing the intermediate II with a second organic solvent, and reacting with methanol in alkali and protective gas atmosphere to obtain the 1, 4-dimethoxy tetrafluorobenzene. The synthesis method of the 1, 4-dimethoxy tetrafluorobenzene has the advantages of mild reaction conditions, no need of harsh conditions, high controllability, simple post-treatment, easiness in operation, capability of effectively improving the overcharge resistance of the lithium ion battery and the like.
REACTION OF AROMATIC COMPOUNDS WITH NUCLEOPHILIC REAGENTS IN LIQUID AMMONIA. V. THE MECHANISM AND DIRECTION OF HYDROXYLATION OF p-SUBSTITUTED NITROBENZENES WITH POTASSIUM HYDROXIDE
Malykhin, E. V.,Kolesnichenko, G. A.,Shteingarts, V. D.
, p. 1048 - 1056 (2007/10/02)
In the reaction of p-substituted nitrobenzenes 4-XC6H4NO2 (X = Cl, Br, I) with potassium hydroxide and oxygen in liquid ammonia (-33 deg C) the corresponding 5-substituted 2-nitrophenols are formed with high yields.Under analogous conditions 4-fluoronitrobenzene and 1,4-dinitrobenzene are converted into 4-nitrophenol.When K18OH was used, the hydroxyl group of the reaction products contained the 18O isotope preferentially in both cases.The action of KO2 and K2O2 in the presence of oxygen on 4-chloronitrobenzene or of oxygen on the product from the reduction of 4-chloronitrobenzene with potassium leads to the formation of 4-nitrophenol.This set of experimental data agrees with the scheme for the hydroxylation of p-substituted nitrobenzenes with alkali and oxygen in liquid ammonia involving the formation of anionic ? complexes for both directions of the process and their oxidation by molecular oxygen in the case of substitution of a hydrogen atom.