36288-37-6

Basic information

• Product Name: N-hydroxy-4-methylbenzenecarboximidoyl chloride
• Synonyms: N-hydroxy-4-methylbenzenecarboximidoyl chloride
• CAS NO: 36288-37-6
• Molecular Weight: 169.611
• Mol File: 36288-37-6.mol
• Article Data: 96

Chemical Properties

• CAS DataBase Reference: N-hydroxy-4-methylbenzenecarboximidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: N-hydroxy-4-methylbenzenecarboximidoyl chloride(36288-37-6)
• EPA Substance Registry System: N-hydroxy-4-methylbenzenecarboximidoyl chloride(36288-37-6)

Safety Data

• Hazardous Substances Data: 36288-37-6(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 3717-16-6 (Z)-4-methylbenzaldehyde oxime 
• 3235-02-7 p-methylbenzaldehyde oxime 
• 3717-15-5 p-methylbenzaldehyde oxime 
• 589-18-4 4-Methylbenzyl alcohol 
• 459-23-4 (E)-4-fluorobenzaldehyde oxime 
• 128-09-6 N-chloro-succinimide 

Downstream Products

• 54697-02-8 3,6-di-p-tolyl-1,4,2,5-dioxadiazine 
• 26218-73-5 3,4-bis(4-methylphenyl)-1,2,5-oxadiazole-N-oxide 
• 125324-43-8 (3aR,9aR)-3,8-Di-p-tolyl-3a,9a-dihydro-5aH-isoxazolo[4,5-e][1,2,4]oxadiazolo[4,5-a]pyridine 
• 125324-45-0 (6aR,9aS,9bR)-3,9-Di-p-tolyl-9a,9b-dihydro-6aH-isoxazolo[4,5-c][1,2,4]oxadiazolo[4,5-a]pyridine 
• 78-40-0 triethyl phosphate 
• 87174-57-0 (3-p-Tolyl-[1,2,4]oxadiazol-5-yl)-phosphonic acid diethyl ester 
• 89109-63-7 O-benzoyl-4-methylbenzohydroximoyl chloride 
• 86387-53-3 S-<2-(diethylamino)ethyl>-4-methylbenzothiohydroximate hydrochloride 
• 292605-23-3 2,5-dihydro-3'-(p-tolyl)spiroisoxazolino-[5',5]furan-2-one 
• 828939-54-4 5-[(phenylselanyl)methyl]-3-(p-tolyl)-4,5-dihydroisoxazole 

Relevant articles and documents

Synthesis of 4-(4-ethyl-phenyl)-3-(4-methyl-phenyl)-1,2,4-oxadiazol-5(4H)-one and 4-(4-ethyl-phenyl)-3-(4-methyl-phenyl)-1,2,4-oxadiazole-5(4H)-thione and solvent effects on their infrared spectra in organic solvents

In the present study novel 4-(4-ethyl-phenyl)-3-(4-methyl-phenyl)-1,2,4-oxadiazol-5(4H)-one (compound (4)) and 4-(4-ethyl-phenyl)-3-(4-methyl-phenyl)-1,2,4-oxadiazole-5(4H)-thione (compound (5)) were synthesized. These oxadiazole ring derivatives were cha

Design, synthesis, in vitro and in silico evaluation of new 3-phenyl-4,5-dihydroisoxazole-5-carboxamides active against drug-resistant mycobacterium tuberculosis

A new series of 3-phenyl-4,5-dihydroisoxazole-5-carboxamides were designed, synthesized, and evaluated for their potency against Mtb H37Rv. Designed molecules were synthesized by one-pot cycloaddition reaction in good to excellent yields. Anti-Tubercular evaluation of all synthesized derivatives identified 6k to be highly potent (MIC 1 μg/mL) against Mtb and drug-resistant strains. All potent derivatives were found to be non-toxic when tested against Vero cells. Also, in silico studies were employed to explore the binding patterns of designed compounds to target Mycobacterial membrane protein Large-3. All derivatives exhibited excellent binding patterns with the receptor. The excellent in silico Absorption, Distribution, Metabolism, and Excretion properties and druggability parameters positions these molecules as promising lead candidates for the future development of new drugs to treat drug-resistant Tuberculosis.

Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors

α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.