363135-54-0

Basic information

• Product Name: 7-Hydroxy-3-quinolinecarbaldehyde
• Synonyms: 7-Hydroxy-3-quinolinecarbaldehyde;7-hydroxy-3-quinolinecarbaldehyde(SALTDATA: FREE);7-hydroxyquinoline-3-carbaldehyde;7-Hydroxy-3-quinolinecarboxaldehyde
• CAS NO: 363135-54-0
• Molecular Formula: C₁₀H₇NO₂
• Molecular Weight: 173.16808
• Mol File: 363135-54-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 392.2 °C at 760 mmHg
• Flash Point: 191 °C
• Appearance: /
• Density: 1.364 g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.733
• CAS DataBase Reference: 7-Hydroxy-3-quinolinecarbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Hydroxy-3-quinolinecarbaldehyde(363135-54-0)
• EPA Substance Registry System: 7-Hydroxy-3-quinolinecarbaldehyde(363135-54-0)

Safety Data

• Hazardous Substances Data: 363135-54-0(Hazardous Substances Data)

Usage

General Description

7-Hydroxy-3-quinolinecarbaldehyde is a chemical compound that belongs to the class of heterocyclic compounds. It possesses a quinoline backbone, consisting of a benzene ring fused to a pyrimidine ring with an aldehyde and hydroxyl group attached at specific positions. 7-Hydroxy-3-quinolinecarbaldehyde has potential applications in various fields such as drug development and medicinal chemistry. It is utilized as a versatile building block for the synthesis of diverse pharmaceuticals, as well as a key intermediate in the production of other specialty chemicals. 7-Hydroxy-3-quinolinecarbaldehyde has been studied for its biological activity and shows promise as a potential drug candidate with anti-cancer, anti-inflammatory, and antimicrobial properties.

InChI:InChI=1/C10H7NO2/c12-6-7-3-8-1-2-9(13)4-10(8)11-5-7/h1-6,13H

Upstream product

• 591-27-5 m-Hydroxyaniline 
• 745830-14-2 7-acetoxy-2-chloroquinoline-3-carbaldehyde 
• 6317-89-1 3-acetamidophenyl acetate 

Downstream Products

• 745830-21-1 7-(benzyloxy)quinoline-3-carbaldehyde 

Relevant articles and documents

INHIBITORS OF LEUKOTRIENE PRODUCTION

The present invention relates to compounds of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1 is defined herein. The compounds of formula (I) are useful as inhibitors of leukotriene A4 hydrolase (LTA4H) and treating LTA4H related disorders. The present invention also relates to pharmaceutical compositions comprising the compounds of formula (I), methods of using these compounds in the treatment of various diseases and disorders, and processes for preparing these compounds.

HETEROBICYCLIC SPHINGOSINE 1-PHOSPHATE ANALOGS

Compounds that have agonist activity at one or more of the SlP receptors are provided. The compounds are sphingosine analogs that, after phosphorylation, can behave as agonists at SlP receptors.

An efficient synthesis of substituted quinolines

The addition of substituted anilines to "vinamidinium" bis-tetrafluoroborate salt 1 [2-dimethylaminomethylene-1,3-bis(dimethylimmonio)propane bis-tetrafluoroborate], followed by cyclization of the resulting imino-eneamine salt and hydrolysis of the masked aldehydes 2, provide the corresponding 3-formyl quinolines 3. While the condensation of both 1 and its analogous bis-perchlorate salt and amidines are known to provide pyrimidines, we believe this is the first example of a quinoline annulation sequence with "vinamidinium" bis-tetrafluoroborate salt 1 and anilines.