36357-38-7 Usage
Description
5-Acetyl-2-methylpyridine is an organic compound with the chemical formula C7H7NO. It is a pale-yellow oil at room temperature and is known for its distinct chemical properties. 5-ACETYL-2-METHYLPYRIDINE is a derivative of pyridine, a basic structure found in various pharmaceuticals and chemical products.
Uses
Used in Chemical Synthesis:
5-Acetyl-2-methylpyridine is used as a key intermediate in the preparation of pyridine-2,5-dicarboxylic acid, an important chemical compound with various applications in the chemical and pharmaceutical industries. The synthesis process involves the use of potassium permanganate as an oxidant, which facilitates the conversion of 5-acetyl-2-methylpyridine into the desired product.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 5-acetyl-2-methylpyridine serves as a ligand for Suzuki coupling, a widely used method for the formation of carbon-carbon bonds. This coupling reaction is essential in the synthesis of various complex organic molecules, including those with potential pharmaceutical applications. The use of 5-acetyl-2-methylpyridine as a ligand enhances the efficiency and selectivity of the Suzuki coupling process, leading to the production of desired compounds with improved yields and purity.
Used in Material Science:
The unique chemical properties of 5-acetyl-2-methylpyridine also make it a valuable compound in the field of material science. Its ability to form stable complexes with various metal ions can be exploited in the development of new materials with specific properties, such as catalysts, sensors, or advanced materials for energy storage and conversion.
Check Digit Verification of cas no
The CAS Registry Mumber 36357-38-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,3,5 and 7 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 36357-38:
(7*3)+(6*6)+(5*3)+(4*5)+(3*7)+(2*3)+(1*8)=127
127 % 10 = 7
So 36357-38-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO/c1-5(10)6-2-3-7(8)9-4-6/h2-4H,1H3
36357-38-7Relevant articles and documents
PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF
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Paragraph 0261; 0262, (2018/07/29)
The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof: and the process of making the intermediate of Formula III: wherein PG is as defined as set forth in the specification.
Palladium-catalyzed acetylation of arenes
Ramgren, Stephen D.,Garg, Neil K.
supporting information, p. 824 - 827 (2014/03/21)
A simple method for the preparation of aryl methyl ketones is reported. The transformation involves the Pd-catalyzed coupling of an acyl anion equivalent, acetyltrimethylsilane, with aryl bromides to afford the corresponding acetylated arenes in synthetically useful yields. The methodology is tolerant of heterocycles and provides a new method for arene functionalization.
PROCESS FOR PREPARING 1-(6-METHYLPYRIDIN-3-YL)-2-[4-(METHYLSULFONYL)PHENYL]ETHANONE, AN INTERMEDIATE OF ETORICOXIB
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, (2012/09/22)
A process for preparing 1-(6-methylpyridin-3-yl)-2-[4-(methyl sulfonyl)phenyl]ethanone, an intermediate of the synthesis of Etoricoxib. The synthesis of the intermediates useful for such preparation is also described.