36404-90-7 Usage
Description
2-Fluoro-3-formylpyridine is an organic compound that features a pyridine ring with a fluorine atom at the 2nd position and a formyl group (aldehyde) at the 3rd position. This unique structure endows it with specific chemical properties that make it a versatile building block in organic synthesis and a potential candidate for various applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
2-Fluoro-3-formylpyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its presence in the molecular structure can influence the biological activity and pharmacokinetic properties of the resulting drugs, making it a valuable component in drug discovery and development.
Used in Organic Synthesis:
In the field of organic synthesis, 2-Fluoro-3-formylpyridine is utilized as a building block for the creation of complex organic molecules. Its reactivity and functional groups allow for a range of chemical reactions, such as nucleophilic substitution, to produce a variety of derivatives with different properties and applications.
Used in the Synthesis of Naphthyridines:
2-Fluoro-3-formylpyridine is used as a precursor in the synthesis of naphthyridines, a class of nitrogen-containing heterocyclic compounds with potential applications in medicinal chemistry. The attachment of isoxazolinones through a displacement of the fluoride group, followed by hydrogenolysis and cyclization, leads to the formation of naphthyridine derivatives with potential biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 36404-90-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,6,4,0 and 4 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 36404-90:
(7*3)+(6*6)+(5*4)+(4*0)+(3*4)+(2*9)+(1*0)=107
107 % 10 = 7
So 36404-90-7 is a valid CAS Registry Number.
36404-90-7Relevant articles and documents
Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning
Timperley, Christopher M.,Banks, R. Eric,Young, Ian M.,Haszeldine, Robert N.
scheme or table, p. 541 - 547 (2011/09/15)
Fluoroheterocyclic aldoximes were screened as therapeutic agents for the treatment of anticholinesterase poisoning. 2-Fluoropyridine-3- and -6-aldoxime, and 3-fluoropyridine-2- and -4-aldoxime, were synthesised. Attempts to obtain 3,5,6-trifluoropyridine-2,4-bis(aldoxime) and -2-aldoxime, however, proved unsuccessful. Pentafluorobenzaldoxime was prepared by oximation of pentafluorobenzaldehyde. Acid dissociation constants (pKa) and second-order rate constants (kox-) of the fluorinated pyridinealdoximes towards sarin were measured. 2,3,5,6-Tetrafluoropyridine-4- aldoxime had the best profile: its kox- approached that of the therapeutic oxime P2S (310 vs. 120 l mol-1 min-1), but its higher pKa (9.1 vs. 7.8) fell short of the target figure of 8 required for reactivation of inhibited acetylcholinesterase in vivo. N-alkylation of the fluorinated pyridine-aldoximes may reduce their pK a nearer to 8 and enhance their therapeutic potential. Crown Copyright
USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS
-
Page 7-8, (2010/02/09)
Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.
Le phenyl-lithium: nouvel agent de metallation du cycle pyridinique
Mallet, Marc
, p. 49 - 56 (2007/10/02)
Nucleophilic addition was the sole reaction of phenyl-lithium with a pyridinic ring; now the novel catalysed metallation, with phenyl-lithium, of many substituted pyridine compounds giving various derivatives in high yields with many different reagents, has been achieved.